Role of Helicobacter pylori in gastric carcinogenesis (Reprinted from Gastroenterology Clinics of North America, vol 31, pg 517, 2002)

被引：0

作者：

Sepulveda, AR

Graham, DY

机构：

[1] Univ Pittsburgh, Med Ctr, Dept Pathol, Pittsburgh, PA 15213 USA

[2] Vet Affairs Med Ctr, Digest Dis Sect, Houston, TX 77030 USA

[3] Baylor Coll Med, Dept Med, Houston, TX 77030 USA

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2003年 / 17卷 / 02期

关键词：

D O I：

10.1016/S0889-8588(03)00021-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Peptic ulcers and gastric malignancies are the two major complication of the course of Helicobacter pylori-associated chronic gastritis. Both gastric adenocarcinomas and MALT lymphomas occur in association with H pylori infection, and studies support an etiological association. This article discusses the natural history of H pylori-related gastric carcinogenesis and criteria to identify people susceptible to H pylori infection-associated gastric cancer. It then reviews the molecular and genetic mechanisms underlying the malignant transformation of the gastric mucosa associated with H pylori.

引用

页码：505 / +

页数：20

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