Arsenic-induced APL differentiation in cerebrospinal fluid

被引：14
|
作者：
Helwig, Annett
Klemm, Matthias
Schuettig, Reinhard
Roellig, Christoph
Wassilew, Nasstasja
Ehninger, Gerhard
Illmer, Thomas
机构：
[1] Univ Hosp Tech Univ, Med Clin & Policlin 1, D-01307 Dresden, Germany
[2] Hosp Dresden Friedrichstadt, Inst Clin Chem, Dresden, Germany
来源：
LEUKEMIA RESEARCH | 2007年 / 31卷 / 05期
关键词：
APL; cerebrospinal fluid; treatment; arsenic trioxide;
D O I：
10.1016/j.leukres.2006.06.011
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Although new approaches have dramatically improved, the treatment of acute promyelocytic leukemia (APL) involvement of the central nervous system (CNS) confers a bad prognosis in the disease. Here, we report a patient who was diagnosed with relapsed APL preferentially involving the CNS. Treatment with arsenic trioxide led to impressive morphological changes in CNS cellularity consistent with the induction of a differentiation syndrome. Since arsenic trioxide could be identified in the CNS, we provide evidence that the drug can cross the blood-brain barrier and can be used for treatment of extramedullary APL. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：703 / 705
页数：3
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