Vibrational spectroscopic study of salbutamol hemisulphate

被引：21
|
作者：
Ali, H. R. H. [1 ,3 ]
Edwards, H. G. M. [1 ]
Kendrick, J. [2 ]
Scowen, I. J. [1 ]
机构：
[1] Univ Bradford, Chem & Forens Sci Univ Analyt Ctr, Sch Life Sci, Bradford BD7 1DP, W Yorkshire, England
[2] Univ Bradford, Inst Pharmaceut Innovat, Bradford BD7 1DP, W Yorkshire, England
[3] Univ Assiut, Fac Pharm, Dept Pharmaceut Analyt Chem, Assiut, Egypt
来源：
DRUG TESTING AND ANALYSIS | 2009年 / 1卷 / 1-2期
关键词：
Raman spectroscopy; infrared spectroscopy; salbutamol hemisulphate; beta(2) agonist; quantum chemical calculations; GAS-CHROMATOGRAPHY; DENSITY;
D O I：
10.1002/dta.8
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Salbutamol hemisulphate is a relatively selective beta(2)-adrenergic agonist and is used as a bronchodilator. In this work, we present a detailed vibrational spectroscopic investigation of salbutamol hemisulphate using mid-infrared and near-infrared Fourier-transform (NIR-FT) Raman spectroscopies. These data are supported by quantum chemical calculations, which allow us to characterise the vibrational spectra of this compound reasonably. As such, this study could be viable for examining the way in which this drug interacts with its target molecules. Copyright (C) 2009 John Wiley & Sons, Ltd.
引用
收藏
页码：51 / 56
页数：6
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