Anti-programmed Death-1 Immunotherapy for Endometrial Cancer with Microsatellite Instability-High Tumors

被引：11
|
作者：
Sobecki-Rausch, Janelle [1 ]
Barroilhet, Lisa [1 ]
机构：
[1] Univ Wisconsin, Sch Med & Publ Hlth, Div Gynecol Oncol, 600 Highland Ave, Madison, WI 53792 USA
来源：
CURRENT TREATMENT OPTIONS IN ONCOLOGY | 2019年 / 20卷 / 11期
关键词：
Anti-PD-1; treatment; Endometrial cancer; Microsatellite instability; Mismatch repair deficiency; Pembrolizumab; IMMUNE CHECKPOINT INHIBITORS; LYNCH SYNDROME; OPEN-LABEL; PEMBROLIZUMAB; SAFETY;
D O I：
10.1007/s11864-019-0679-5
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Among gynecologic malignancies, mismatch repair-deficient endometrial cancers show the greatest response to anti-programmed cell death-1 (PD-1) antibodies, such as pembrolizumab. Routine immunohistochemical (IHC) and molecular testing should be performed on all endometrial cancers at the time of diagnosis in order to identify endometrial cancers with mismatch repair deficiency that may show improved response to anti-PD-1 therapy in the progressive or metastatic setting. Institutional effort to enroll patients in clinical trials investigating the use of immune checkpoint inhibitors in endometrial cancer should be prioritized.
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页数：10
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