Structure and catalytic mechanisms of leukotriene A4 hydrolase

被引：38

作者：

Haeggstrom, Jesper Z. ^{[1
]}

Tholander, Fredrik ^{[1
]}

Wetterholm, Anders ^{[1
]}

机构：

[1] Karolinska Inst, Div Chem 2, Dept Med Biochem & Biophys, S-17177 Stockholm, Sweden

来源：

PROSTAGLANDINS & OTHER LIPID MEDIATORS | 2007年 / 83卷 / 03期

关键词：

leukotriene; 5-lipoxygenase; LTA4; hydrolase;

D O I：

10.1016/j.prostaglandins.2007.01.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Leukotriene A4 hydrolase catalyzes the final and committed step in the biosynthesis of leukotriene B4, a potent chemotactic agent for neutrophils, eosinophils, monocytes, and T-cells that play key roles in the innate immune response. Recent data strongly implicates leukotriene B4 in the pathogenesis of cardiovascular diseases, in particular arteriosclerosis, myocardial infarction and stroke. Here, we highlight the most salient features of leukotriene A4 hydrolase with emphasis on its biochemistry and structure biology. (C) 2007 Elsevier Inc. All rights reserved.

引用

页码：198 / 202

页数：5

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