New aryldithiolethione derivatives as potent histone deacetylase inhibitors

被引：19

作者：

Tazzari, Valerio ^{[1
]}

Cappelletti, Graziella ^{[2
]}

Casagrande, Manolo ^{[3
]}

Perrino, Elena ^{[1
]}

Renzi, Luigi ^{[3
]}

Del Soldato, Piero ^{[1
]}

Sparatore, Anna ^{[1
,3
]}

机构：

[1] Sulfidris Srl, I-20131 Milan, Italy

[2] Univ Milan, Dept Biol, I-20133 Milan, Italy

[3] Univ Milan, Dept Pharmaceut Sci Pietro Pratesi, I-20133 Milan, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2010年 / 18卷 / 12期

关键词：

Histone deacetylase inhibitor; Dithiolethione derivatives; Anticancer agents; HYDROGEN-SULFIDE; CANCER-THERAPY; RAT; INDUCTION; ACID; 3H-1,2-DITHIOLE-3-THIONE; CARDIOPROTECTION; MODULATION; PROTECTION; TOXICITY;

D O I：

10.1016/j.bmc.2010.05.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of dithiolethione derivatives was synthesized and the in vitro HDAC inhibitory activity was tested. The most active compounds, 1 and 2, exhibited an IC50 in nM range with a strong hyperacetylation of histone H4 in A549 cells. The HDAC inhibitory activity comparable to that of SAHA and the inhibition of A549 cell proliferation suggest that these compounds are worthy of further studies as potential anticancer agents. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：4187 / 4194

页数：8

共 50 条

[1] Development of novel ferulic acid derivatives as potent histone deacetylase inhibitors
Wang, Fang
Lu, Wen
Zhang, Tao
Dong, Jinyun
Gao, Hongping
Li, Pengfei
Wang, Sicen
Zhang, Jie
BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 21 (22) : 6973 - 6980
[2] Discovery of a series of hydroximic acid derivatives as potent histone deacetylase inhibitors
Zhang, Lei
Wang, Xuejian
Li, Xiaoguang
Zhang, Lihui
Xu, Wenfang
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2014, 29 (04) : 582 - 589
[3] Thioester derivatives of the natural product psammaplin A as potent histone deacetylase inhibitors
Baud, Matthias G. J.
Leiser, Thomas
Petrucci, Vanessa
Gunaratnam, Mekala
Neidle, Stephen
Meyer-Almes, Franz-Josef
Fuchter, Matthew J.
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, 2013, 9 : 81 - 88
[4] Design, Synthesis, and Biological Evaluation of New Urushiol Derivatives as Potent Class I Histone Deacetylase Inhibitors
Zhou, Hao
Qi, Zhiwen
Liu, Danyang
Xue, Xingyin
Wang, Chengzhang
CHEMBIOCHEM, 2023,
[5] Histone deacetylase inhibitors are potent radiation protectants
Paoluzzi, L
Figg, WD
CANCER BIOLOGY & THERAPY, 2004, 3 (07) : 612 - 613
[6] Novel hydroxamate and anilide derivatives as potent histone deacetylase inhibitors: Synthesis and antiproliferative evaluation
Bouchain, G
Delorme, D
CURRENT MEDICINAL CHEMISTRY, 2003, 10 (22) : 2359 - 2372
[7] Discovery of indole-3-butyric acid derivatives as potent histone deacetylase inhibitors
Chen, Yiming
Zhang, Lihui
Zhang, Lin
Jiang, Qixiao
Zhang, Lei
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2021, 36 (01) : 425 - 436
[8] Design, synthesis and biological evaluation of novel isoindolinone derivatives as potent histone deacetylase inhibitors
Chen, Xin
Zhao, Shuang
Li, Hongmei
Wang, Xin
Geng, Aixin
Cui, Hao
Lu, Tao
Chen, Yadong
Zhu, Yong
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 168 : 110 - 122
[9] A series of novel, potent, and selective histone deacetylase inhibitors
Jones, Philip
Altamura, Sergio
Chakravarty, Prasun K.
Cecchetti, Ottavia
De Francesco, Raffaele
Gallinari, Paola
Ingenito, Raffaele
Meinke, Peter T.
Petrocchi, Alessia
Rowley, Michael
Scarpelli, Rita
Serafini, Sergio
Steinkuhler, Christian
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (23) : 5948 - 5952
[10] Histone deacetylase inhibitors as potent modulators of cellular contacts
Vinken, Mathieu
Peggy, Papeleu
Vera, Rogiers
Tamara, Vanhaecke
CURRENT DRUG TARGETS, 2006, 7 (06) : 773 - 787

← 1 2 3 4 5 →