Combined effects of 3D bone marrow stem cell-seeded wet-electrospun poly lactic acid scaffolds on fa-thickness skin wound healing

被引：20

作者：

Ghorbani, Sadegh ^{[1
]}

Eyni, Hossein ^{[1
]}

Tiraihi, Taki ^{[1
]}

Asl, Leila Salari ^{[1
]}

Soleimani, Masoud ^{[2
]}

Atashi, Amir ^{[3
]}

Beiranvand, Shahram Pour ^{[1
]}

Warkiani, Majid Ebrahimi ^{[4
,5
]}

机构：

[1] Tarbiat Modares Univ, Sch Med Sci, Dept Anat Sci, POB 14155-4838, Tehran, Iran

[2] Tarbiat Modares Univ, Sch Med Sci, Dept Hematol, Tehran, Iran

[3] Shahroud Univ Med Sci, Stem Cell & Tissue Engn Res Ctr, Shahroud, Iran

[4] Univ New South Wales, Australian Ctr Nanomed, Sch Mech & Mfg Engn, Sydney, NSW, Australia

[5] Garvan Inst Med Res, Sydney, NSW, Australia

来源：

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2018年 / 67卷 / 15期

关键词：

3D nanofiber scaffold; poly lactic acid scaffold; skin tissue engineering; wet electrospinning; wound healing; DERMAL RECONSTRUCTION; NANOFIBERS; COLLAGEN; KERATINOCYTES; REGENERATION; FIBROBLASTS; DELIVERY; GROWTH; OXYGEN;

D O I：

10.1080/00914037.2017.1393681

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Tissue engineering has emerged as an alternative treatment to traditional grafts for skin wound healing. Three-dimensional nanofibers have been used extensively for this purpose due to their excellent biomedical-related properties. In this study, high porous 3D poly lactic acid nanofibrous scaffolds (PLA-S) were prepared by wet-electrospinning technique and seeded with rat bone-marrow stem cells (BMSCs) to characterize the biocompatibility and therapeutic efficacy of these fibers on the treating full-thickness dermal wounds. The results of in vitro andin vivo studies indicate that the 3D fibrous PLA-S can be a potential wound dressing for wound repair, particularly when seeded with BMSCs. [GRAPHICS] .

引用

页码：905 / 912

页数：8

共 13 条

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