Regulation of kynurenic acid levels in the developing rat brain

被引：11
|
作者：
Schwarcz, R [1 ]
Poeggeler, B [1 ]
Rassoulpour, A [1 ]
Ceresoli-Borroni, G [1 ]
Hodgkins, PS [1 ]
机构：
[1] Univ Maryland, Sch Med, Maryland Psychiat Res Ctr, Baltimore, MD 21228 USA
来源：
AMINO ACIDS | 1998年 / 14卷 / 1-3期
关键词：
excitotoxicity; glia; kynurenines; neuroprotection; ontogeny;
D O I：
10.1007/BF01345270
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Several brain-specific mechanisms control the formation of the endogenous excitatory amino acid receptor antagonist kynurenic acid (KYNA) in the adult rat brain. Two of these, dopaminergic neurotransmission and cellular energy metabolism, were examined in the brain of immature (postnatal day 7) rats. The results indicate that during the early postnatal period cerebral KYNA synthesis is exceptionally amenable to modulation by dopaminergic mechanisms but rather insensitive to fluctuations in cellular energy status. These findings may be of relevance for the role of KYNA in the function and dysfunction of the developing brain.
引用
收藏
页码：243 / 249
页数：7
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