A method for cranial target delineation in radiotherapy treatment planning aided by single-voxel magnetic resonance spectroscopy: evaluation using a custom-designed gel-based phantom and simulations

被引：2

作者：

Zeinali-Rafsanjani, Banafsheh ^{[1
,2
]}

Mosleh-Shirazi, Mohammad Amin ^{[3
,4
]}

Faghihi, Reza ^{[2
,5
]}

Saeedi-Moghadam, Mahdi ^{[1
]}

Lotfi, Mehrzad ^{[1
]}

Jalli, Reza ^{[1
]}

机构：

[1] Shiraz Univ Med Sci, Med Imaging Res Ctr, Shiraz, Iran

[2] Shiraz Univ, Sch Mech Engn, Dept Nucl Engn, Shiraz, Iran

[3] Shiraz Univ Med Sci, Ionizing & Nonionizing Radiat Protect Res Ctr, Sch Paramed Sci, Shiraz, Iran

[4] Shiraz Univ Med Sci, Radiotherapy & Oncol Dept, Shiraz, Iran

[5] Shiraz Univ, Radiat Res Ctr, Sch Mech Engn, Shiraz, Iran

来源：

BRITISH JOURNAL OF RADIOLOGY | 2019年 / 92卷 / 1104期

关键词：

PROTON MR SPECTROSCOPY; HIGH-GRADE GLIOMAS; BRAIN-TUMORS; CEREBRAL GLIOMAS; LESIONS; ACCURACY; IMRT; DIFFERENTIATION; DISTINCTION; DIFFUSION;

D O I：

10.1259/bjr.20190216

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Objective: Magnetic resonance spectroscopy (MRS) has been useful in radiotherapy treatment planning (RIP) especially in tumor delineation. Routinely, 2D/3D MRSI data are used for this application. However, not all centers have access to 2D/3D MRSI. The objective of this study was to introduce a method of using single-voxel spectroscopy (SVS) data in target delineation and assess its reliability. Methods: A gel-based phantom containing Creatine (Cr), N-acetyl-l-aspartic-acid (NAA), and Choline (Cho) was designed and built. The metabolite ratios simulate the normal and tumoral part of the brain. The jMRUI software (v. 6.0) was used to simulate a 1.5 T GE MRI scanner. The metabolite spectra provided by different time of echos (TE)s of the Point-RESolved Spectroscopy pulse-sequence (PRESS), different data-points, and post-processings were quantized by IMRUI. PseudoMRSI maps of Cho/Cr, NAA/Cr, and Cho + Cr/NAA were created. A conformity index (CI) was used to determine which metabolite-ratio isolines are more appropriate for tumor delineation. Results: The simulation accuracy was verified. There were no differences > 4% between the measured and simulated spectra in peak regions. The pseudoMRSI map of Cho + Cr/NAA smoothly followed the complicated geometry of the tumor inside the gel-based phantom, The results showed that the single-voxel spectra produced by the PRESS pulse sequence with the TE of 144 ms, 512 data-points, and minimum post-processings of water suppression, eddy current correction, and baseline correction can be used for target delineation. Conclusion: This study suggests that SVS data can be used to aid target delineation by using a mathematical approach. This can enable a wider use of MR-derived information in radiotherapy. Advances in knowledge: To the best of our knowledge, until now, 2D or 3D MRSI data provided from 3T MRI scanners have been used for MRS-based radiotherapy treatment planning. However, there are a lot of centers that are equipped to 1.5 T MRI scanners and some of them just equipped to SVS. This study introduces a mathematical approach to help these centers to take the benefits of MRS-based treatment planning.

引用

页数：10