SprB Is the Molecular Link between Salmonella Pathogenicity Island 1 (SPI1) and SPI4

被引:20
|
作者
Saini, Supreet [1 ]
Rao, Christopher V. [1 ]
机构
[1] Univ Illinois, Dept Chem & Biomol Engn, Urbana, IL 61801 USA
关键词
ENTERICA SEROVAR TYPHIMURIUM; III SECRETION SYSTEM; NEEDLE COMPLEX; EXPRESSION; HILA; REGULATOR; INVASION; GENES; IDENTIFICATION; ACTIVATION;
D O I
10.1128/JB.00047-10
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Salmonella pathogenicity island 1 (SPI1) and SPI4 have previously been shown to be jointly regulated. We report that SPI1 and SPI4 gene expression is linked through a transcriptional activator, SprB, encoded within SPI1 and regulated by HilA. SprB directly activates SPI4 gene expression and weakly represses SPI1 gene expression through HilD.
引用
收藏
页码:2459 / 2462
页数:4
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