Cardiopulmonary Exercise Responses in Individuals with Metabolic Syndrome: The Ball State Adult Fitness Longitudinal Lifestyle Study

被引:3
|
作者
Rodriguez, Julio C. [1 ]
Peterman, James E. [2 ]
Fleenor, Bradley S. [1 ]
Whaley, Mitchell H. [1 ]
Kaminsky, Leonard A. [2 ]
Harber, Matthew P. [1 ]
机构
[1] Ball State Univ, Human Performance Lab, Clin Exercise Physiol, Muncie, IN 47306 USA
[2] Ball State Univ, Fisher Inst Hlth & Well Being, Muncie, IN 47306 USA
关键词
ventilation; ventilatory efficiency; OUES; ventilatory threshold; VE; VCO2slope; UPTAKE EFFICIENCY SLOPE; TESTING DATA ASSESSMENT; OXYGEN-UPTAKE; VENTILATORY THRESHOLD; CARDIORESPIRATORY FITNESS; CLINICAL RECOMMENDATIONS; CARDIOVASCULAR-DISEASE; REFERENCE-STANDARDS; CAROTID-BODY; ALL-CAUSE;
D O I
10.1089/met.2021.0130
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Background: The association between cardiorespiratory fitness (CRF) and metabolic syndrome (MetSyn) is well established. Additional variables derived from cardiopulmonary exercise testing (CPET) have shown prognostic value in some chronic diseases, however, there is limited information on how cardiopulmonary responses to exercise may be altered in individuals with MetSyn. Thus, the purpose of this study was to examine the association between cardiopulmonary variables derived from CPET and MetSyn.Methods: A cohort of 3181 participants (1714 men, 1467 women), aged 20-79 years, completed CPET and metabolic risk factor assessment between January 1, 1971, and November 1, 2020. Cardiopulmonary variables assessed included CRF defined as the maximum volume of oxygen uptake (VO2max), ventilatory threshold (VO2@VT), oxygen uptake efficiency slope (OUES), the ratio of ventilation to VO2 at peak exercise (peak V-E/VO2) and the V-E/VCO2slope. MetSyn was defined using the National Cholesterol Education Program/Adult Treatment Panel.Results: VO2max, VO2@VT, and OUES were lower (P < 0.001) and V-E/VCO2slope was higher (P < 0.001) in individuals with MetSyn (n = 774), whereas no difference between groups existed for peak V-E/VO2. Logistic regression analysis revealed that VO2max [0.91, 0.89-0.93; odds ratio (OR), 95% confidence interval (CI)], VO2@VT (0.91, 0.87-0.95; OR, 95% CI), OUES (0.32, 0.20-0.52; OR, 95% CI), and V-E/VCO2slope (1.03, 1.01-1.05 OR, 95% CI) were all associated with the presence of MetSyn (P <= 0.001).Conclusion: These results indicate that MetSyn is associated with altered cardiopulomary function that may provide insight into the underlying pathophysiology of MetSyn.
引用
收藏
页码:414 / 420
页数:7
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