Mannan-binding lectin (MBL) in two chicken breeds and the correlation with experimental Pasteurella multocida infection

被引：32
|
作者：
Schou, T. W. [1 ,2 ]
Permin, A. [1 ,2 ]
Christensen, J. P. [1 ]
Cu, H. P. [3 ]
Juul-Madsen, H. R. [4 ]
机构：
[1] Univ Copenhagen, Fac Life Sci, Dept Vet Pathobiol, DK-1870 Frederiksberg C, Denmark
[2] DHIgrp, Dept Human Hlth & Safety, DK-2970 Horsholm, Denmark
[3] Natl Inst Vet Res, Dept Bacteriol, Hanoi, Vietnam
[4] Univ Aarhus, Dept Anim Hlth Welf & Nutr, Res Ctr Foulum, Fac Agr Sci, DK-8830 Tjele, Denmark
来源：
COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES | 2010年 / 33卷 / 03期
关键词：
Mannan-binding lectin; MBL; Innate immunity; Humoral immunity; Pasteurella multocida; Chickens; FOWL CHOLERA; SERUM-LEVELS; BRONCHITIS VIRUS; SERINE-PROTEASE; GENE-MUTATIONS; ASSOCIATION; COMPLEMENT; COLLECTINS; DISEASE; TURKEYS;
D O I：
10.1016/j.cimid.2008.08.010
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The present study is the first demonstration of an association of the genetic serum Mannan-binding lectin (MBL) concentration with bacterial infections in chickens. The genetic serum MBL concentration was determined in two chicken breeds, and the association with the specific Pasteurella multocida humoral immune response during an experimental infection was examined. Furthermore, we examined the association of the genetic serum MBL concentration with systemic infection. The chickens with systemic infection had a statistically significant lower mean serum MBL concentration than the rest of the chickens, suggesting that MBL plays an important role against P. multocida. A statistically significant negative correlation was found between the specific antibody response and the genetic serum MBL concentration for both breeds. This indicates that MBL in chickens is capable of acting as the first line of defence against P multocida by diminishing the infection before the adaptive immune response takes over. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：183 / 195
页数：13
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