Liver-specific deletion of Mttp versus Tm6sf2 reveals distinct defects in stepwise VLDL assembly

被引：3
|
作者：
Newberry, Elizabeth P. [1 ]
Strout, Gregory W. [2 ]
Fitzpatrick, James A. J. [2 ,3 ,4 ,5 ]
Davidson, Nicholas O. [1 ]
机构：
[1] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA
[2] Washington Univ, Ctr Cellular Imaging, St Louis, MO 63110 USA
[3] Washington Univ, Sch Med, Dept Cell Biol, St Louis, MO 63110 USA
[4] Washington Univ, Sch Med, Dept Physiol & Neurosci, St Louis, MO USA
[5] Washington Univ, Dept Biomed Engn, St Louis, MO 63110 USA
来源：
JOURNAL OF LIPID RESEARCH | 2021年 / 62卷
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/j.jlr.2021.100080
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页数：2
相关论文
共 50 条
  • [1] Liver-Specific Deletion of Mouse Tm6sf2 Promotes Steatosis, Fibrosis, and Hepatocellular Cancer
    Newberry, Elizabeth P.
    Hall, Zoe
    Xie, Yan
    Molitor, Elizabeth A.
    Bayguinov, Peter O.
    Strout, Gregory W.
    Fitzpatrick, James A. J.
    Brunt, Elizabeth M.
    Griffin, Julian L.
    Davidson, Nicholas O.
    HEPATOLOGY, 2021, 74 (03) : 1203 - 1219
  • [2] Defects in TM6SF2 Impairs Lipidation of Nascent VLDL and Leads to Accumulation of Liver Fat
    Martin, Sarah A.
    Smagris, Eriks
    Cohen, Jonathan C.
    Hobbs, Helen H.
    FASEB JOURNAL, 2018, 32 (01):
  • [3] LIVER SPECIFIC DELETION OF TM6SF2 PROMOTES BOTH HEPATIC FIBROSIS AND HEPATOCELLULAR CANCER
    Newberry, Elizabeth P.
    Hall, Zoe
    Xie, Yan
    Molitor, Elizabeth A.
    Brunt, Elizabeth M.
    Griffin, Jules
    Davidson, Nicholas O.
    GASTROENTEROLOGY, 2020, 158 (06) : S1267 - S1267
  • [4] LIVER SPECIFIC DELETION OF Tm6sf2 PROMOTES BOTH HEPATIC FIBROSIS AND HEPATOCELLULAR CANCER
    Newberry, Elizabeth
    Hall, Zoe
    Xie, Yan
    Molitor, Elizabeth
    Brunt, Elizabeth M.
    Griffin, Jules L.
    Davidson, Nicholas O.
    HEPATOLOGY, 2020, 72 : 337A - 338A
  • [5] Tm6sf2 is a Regulator of Liver Fat Metabolism in Smooth Er Influencing Vldl Lipidation
    Luo, Fei
    Hobbs, Helen H.
    Cohen, Jonathan C.
    CIRCULATION, 2020, 142
  • [6] Basic and translational evidence supporting the role of TM6SF2 in VLDL metabolism
    Liu, Jing
    Ginsberg, Henry N.
    Reyes-Soffer, Gissette
    CURRENT OPINION IN LIPIDOLOGY, 2024, 35 (03) : 157 - 161
  • [7] Isolated Liver Perfusion and Electron Microscopy Reveal Defect in Vldl Lipidation Associated With Inactivation of Tm6sf2
    Luo, Fei
    Fletcher, Justin A.
    Smagris, Eriks
    Burgess, Shawn C.
    Cohen, Jonathan C.
    Hobbs, Helen H.
    CIRCULATION, 2021, 144
  • [8] Hypolipidemia associated with inactivation of TM6SF2 is due to decreased VLDL-lipids secretion
    Luo, F.
    Smagris, E.
    Fletcher, J. A.
    Cohen, J. C.
    Hobbs, H. H.
    EUROPEAN HEART JOURNAL, 2021, 42 : 3371 - 3371
  • [9] Ligand Discovery for TM6SF2, a Novel Target for Liver Disease
    Reevey, Liatris
    Alon, Assaf
    Yang, Yixi
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2025, 392 (03):
  • [10] Hepatic TM6SF2 Is Required for Lipidation of VLDL in a Pre-Golgi Compartment in Mice and Rats
    Luo, Fei
    Smagris, Eriks
    Martin, Sarah A.
    Vale, Goncalo
    McDonald, Jeffrey G.
    Fletcher, Justin A.
    Burgess, Shawn C.
    Hobbs, Helen H.
    Cohen, Jonathan C.
    CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 2022, 13 (03): : 879 - 899
12345