Synthesis of indole-fused 4-pyridone-3-carboxylic acids

被引：0
|
作者：
Song, HJ
Kim, MY
Kang, SB
Chung, BY
Kim, Y
机构：
[1] Korea Inst Sci & Technol, Biochem Res Ctr, Seoul 130650, South Korea
[2] Korea Univ, Dept Chem, Seoul 136701, South Korea
来源：
HETEROCYCLES | 1998年 / 48卷 / 01期
关键词：
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Some indole-fused tri-and tetracyclic 4-oxo-pyridine-3-carboxylic acids, quinolone-type derivatives, (3), (4), and (5) have been prepared. The synthesis is characterized by the construction of the pyridone ring through the intrarmolecular nucleophilic displacement cyclization at the 2-position of 3-substituted 1-methoxyindole accompanied with demethoxylation.
引用
收藏
页码：103 / 112
页数：10
相关论文
共 50 条
  • [1] Synthesis of novel indole-fused heterocycles
    Roy, Sudipta
    Gribble, Gordon W.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2005, 230 : U3408 - U3408
  • [2] TETRABUTYLAMMONIUM FLUORIDE AS A CYCLIZATION AGENT IN THE SYNTHESIS OF ANTIBACTERIAL 4-PYRIDONE-3-CARBOXYLIC ACID-DERIVATIVES
    BOUZARD, D
    DICESARE, P
    ESSIZ, M
    JACQUET, JP
    REMUZON, P
    TETRAHEDRON LETTERS, 1988, 29 (16) : 1931 - 1934
  • [3] ARTHROPATHY INDUCED BY ANTIBACTERIAL FUSED N-ALKYL-4-PYRIDONE-3-CARBOXYLIC ACIDS
    INGHAM, B
    BRENTNALL, DW
    DALE, EA
    MCFADZEAN, JA
    TOXICOLOGY LETTERS, 1977, 1 (01) : 21 - 26
  • [4] PYRIDONECARBOXYLIC ACIDS AS ANTIBACTERIAL AGENTS .1. SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIP OF 1-ARYL-6-(4-DIMETHYLAMINOPHENYL)-4-PYRIDONE-3-CARBOXYLIC ACIDS
    NARITA, H
    KONISHI, Y
    NITTA, J
    NAGAKI, H
    KITAYAMA, I
    WATANABE, Y
    SAIKAWA, I
    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 1986, 106 (09): : 775 - 781
  • [5] Copper-Catalyzed Synthesis of Indole-Fused Benzodiazepines
    Biswas, Subhasish
    Batra, Sanjay
    ADVANCED SYNTHESIS & CATALYSIS, 2011, 353 (14-15) : 2861 - 2867
  • [6] Asymmetric (4+n) Cycloadditions of Indolyldimethanols for the Synthesis of Enantioenriched Indole-Fused Rings
    Zhang, Jia-Yi
    Chen, Jia-Yi
    Gao, Cong-Hui
    Yu, Lei
    Ni, Shao-Fei
    Tan, Wei
    Shi, Feng
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2023, 62 (37)
  • [7] Synthesis of indole-fused benzodiazepine derivatives by photocatalyzed cascade reaction
    Oishi, Tatsushi
    Uchikura, Tatsuhiro
    Akiyama, Takahiko
    CHEMICAL COMMUNICATIONS, 2025, 61 (12) : 2576 - 2579
  • [8] A Convenient Synthesis of Fluoroalkylated Benzimidazole- or Indole-fused Benzoxazines
    Hu, Yijie
    Wang, Xiaoli
    Ren, Nan
    Li, Na
    Li, Jianyang
    Chen, Jie
    Zhang, Hui
    Deng, Hongmei
    Cao, Weiguo
    Lin, Jin-Hong
    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2022, 2022 (05)
  • [9] 4-Pyridone-3-carboxylic acid as a benzoic acid bioisostere: Design, synthesis, and evaluation of EP300/CBP histone acetyltransferase inhibitors
    Kanada, Ryutaro
    Suzuki, Takashi
    Murata, Takeshi
    Miyazaki, Masaki
    Shimada, Takashi
    Kuroha, Mutsumi
    Minami, Megumi
    Higuchi, Saito
    Tominaga, Yuichi
    Naito, Hiroyuki
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2021, 51
  • [10] Enantioselective Synthesis of Indole-Fused Dihydropyranones via Catalytic Cycloaddition of Ketenes and 3-Alkylenyloxindoles
    Lv, Hui
    Chen, Xiang-Yu
    Sun, Li-hui
    Ye, Song
    JOURNAL OF ORGANIC CHEMISTRY, 2010, 75 (20): : 6973 - 6976
12345