Metabolic correction of gas exchange disturbances in rats with barbiturate coma

被引：0
|
作者：
Shefer, TV [1 ]
Ivnitskii, YY [1 ]
Malakhovskii, VN [1 ]
机构：
[1] Mil Med Acad, St Petersburg, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2004年 / 137卷 / 05期
关键词：
barbiturates; coma; oxygen consumption; limiting factor;
D O I：
10.1023/B:BEBM.0000038154.97779.86
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Krebs cycle intermediates normalized gas exchange and decreased the mortality rate in rats with barbiturate coma. Treatment with other substrates including glucose and products of glycolysis was ineffective. Oxygen inhalation had no effect on oxygen consumption and indexes of external respiration. Our results suggest that deficiency of endogenous intermediates of the Krebs cycle, but not disturbances in oxygen mass transfer, serves as a limiting factor for oxygen consumption in rats with barbiturate coma.
引用
收藏
页码：463 / 467
页数：5
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