Two-pore Channels Enter the Atomic Era: Structure of Plant TPC Revealed

被引：16
|
作者：
Patel, Sandip [1 ]
Penny, Christopher J. [1 ]
Rahman, Taufiq [2 ]
机构：
[1] UCL, Dept Cell & Dev Biol, London, England
[2] Univ Cambridge, Dept Pharmacol, Tennis Court Rd, Cambridge CB2 1QJ, England
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 2016年 / 41卷 / 06期
基金：
英国生物技术与生命科学研究理事会;
关键词：
ACTIVATION;
D O I：
10.1016/j.tibs.2016.04.007
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Two-pore channels (TPCs) are intracellular Ca2+-permeable ion channels that are expressed on acidic Ca2+ stores. They are co regulated by voltage and Ca2+ in plant vacuoles and by the second messenger NAADP in animal endolysosomes. Two new studies of plant TPC structures reveal essential features of their architecture and provide mechanistic insight into their workings.
引用
收藏
页码：475 / 477
页数：3
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