Electroanalytical Characteristics of Lercanidipine and its Voltammetric Determination in Pharmaceuticals and Human Serum on Boron-Doped Diamond Electrode

被引：18
|
作者：
Altun, Yuksel [2 ]
Uslu, Bengi [1 ]
Ozkan, Sibel A. [1 ]
机构：
[1] Ankara Univ, Fac Pharm, Dept Analyt Chem, TR-06100 Ankara, Turkey
[2] Gazi Univ, Fac Educ, Dept Chem, Ankara, Turkey
来源：
ANALYTICAL LETTERS | 2010年 / 43卷 / 12期
关键词：
Boron-doped diamond electrode; Dosage form; Lercanidipine; Oxidation; Voltammetry; MASS-SPECTROMETRY METHOD; HANTZSCH 1,4-DIHYDROPYRIDINES; SOLVATOCHROMIC PARAMETERS; CALCIUM-ANTAGONIST; HUMAN PLASMA; REC; 15/2375; LIQUID; ELECTROCHEMISTRY; SUBSTITUTION; PROTONATION;
D O I：
10.1080/00032711003687047
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The electrooxidative behavior and determination of lercanidipine (LRC) were investigated in aqueous acetonitrile medium at a boron-doped diamond electrode using voltammetric techniques. The LRC in selected supporting electrolyte presents a well-defined anodic response at 0.944V, studied by the proposed method. The linear response was obtained in the ranges of 4x10-6 to 2x10-4mmolL-1 range in 0.5mmolL-1 sulfuric acid supporting electrolyte and 1x10-5 to 8x10-5mmolL-1 range in spiked serum sample for square wave voltammetric technique. No electroactive interferences from the excipients and endogenous substances were found in the pharmaceutical dosage form and in the biological sample, respectively.
引用
收藏
页码：1958 / 1975
页数：18
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