Plasma Angiotensin-(1-7) is a Potential Biomarker for Alzheimer's Disease

被引:32
|
作者
Jiang, Teng [1 ]
Tan, Lan [2 ,3 ]
Gao, Qing [1 ]
Lu, Huan [3 ]
Zhu, Xi-Chen [3 ]
Zhou, Jun-Shan [1 ]
Zhang, Ying-Dong [1 ]
机构
[1] Nanjing Med Univ, Nanjing Hosp 1, Dept Neurol, 68 Changle Rd, Nanjing, Jiangsu, Peoples R China
[2] Qingdao Univ, Qingdao Municipal Hosp, Sch Med, Dept Neurol, Qingdao 266071, Peoples R China
[3] Nanjing Med Univ, Qingdao Municipal Hosp, Dept Neurol, Nanjing, Jiangsu, Peoples R China
基金
中国国家自然科学基金; 中国博士后科学基金;
关键词
Alzheimer's disease; Renin-angiotensin system; angiotensin-(1-7); ACE2; plasma; biomarker; EXPRESSION; BRAIN; AXIS;
D O I
10.2174/1567202613666160224124739
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Brain angiotensin-(1-7) (Ang-(1-7)) concentration has been shown to be reduced and inversely correlated with tau pathology in a mouse model of Alzheimer's disease (AD). In this study, to determine whether the concentration of Ang-(1-7) and the activity of its converting enzyme angiotensin-converting enzyme 2 were altered in plasma under AD context, the plasma samples from 110 AD patients and 128 age-and gender-matched controls were screened. In AD patients, the plasma concentration of Ang-(1-7) was significantly reduced (15.63 +/- 4.35pg/mL vs. 19.58 +/- 3.22pg/mL, P<0.001) and positively correlated with cognitive functions (R=0.66, P<0.001). Meanwhile, receiver-operating characteristic analysis showed that the Ang-(1-7) concentration in plasma could distinguish AD patients from controls with the sensitivity and specificity of 69.1% and 74.2%, respectively, when the optimal cut-off value (18.2 pg/mL) was chosen. These findings indicate that plasma Ang-(1-7) may represent a potential biomarker for AD diagnosis, and further suggest an involvement of this heptapeptide in the pathogenesis of this disease.
引用
收藏
页码:96 / 99
页数:4
相关论文
共 50 条
  • [1] Plasma angiotensin-(1-7) is decreased in preeclampsia
    Brosnihan, KB
    Karoly, M
    Merrill, D
    HYPERTENSION, 2000, 36 (04) : 696 - 696
  • [2] Angiotensin-(1-7)
    Santos, Robson Augusto
    HYPERTENSION, 2014, 63 (06) : 1138 - 1147
  • [3] Angiotensin-(1-7) as a biomarker of childhood obesity: Is there a causal relationship?
    Nozato, Yoichi
    Yamamoto, Koichi
    HYPERTENSION RESEARCH, 2021, 44 (09) : 1233 - 1235
  • [4] Angiotensin-(1-7) in hypertension
    Chappell, MC
    Ferrario, CM
    CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION, 1999, 8 (02): : 231 - 235
  • [5] Angiotensin-(1-7): an update
    Santos, RAS
    Campagnole-Santos, MJ
    Andrade, SP
    REGULATORY PEPTIDES, 2000, 91 (1-3) : 45 - 62
  • [6] Angiotensin-(1-7) is Reduced and Inversely Correlates with Tau Hyperphosphorylation in Animal Models of Alzheimer's Disease
    Jiang, Teng
    Zhang, Ying-Dong
    Zhou, Jun-Shan
    Zhu, Xi-Chen
    Tian, You-Yong
    Zhao, Hong-Dong
    Lu, Huan
    Gao, Qing
    Tan, Lan
    Yu, Jin-Tai
    MOLECULAR NEUROBIOLOGY, 2016, 53 (04) : 2489 - 2497
  • [7] Angiotensin-(1-7) is Reduced and Inversely Correlates with Tau Hyperphosphorylation in Animal Models of Alzheimer’s Disease
    Teng Jiang
    Ying-Dong Zhang
    Jun-Shan Zhou
    Xi-Chen Zhu
    You-Yong Tian
    Hong-Dong Zhao
    Huan Lu
    Qing Gao
    Lan Tan
    Jin-Tai Yu
    Molecular Neurobiology, 2016, 53 : 2489 - 2497
  • [8] Angiotensin-(1-7) and Kidney Disease: Friend or Foe
    Velkoska, Elena
    Patel, Sheila K.
    Burrell, Louise M.
    HYPERTENSION, 2013, 62 (03) : E10 - E10
  • [9] Antihypertensive effects of angiotensin-(1-7)
    Chappell, MC
    Iyer, SN
    Diz, DI
    Ferrario, CM
    BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 1998, 31 (09) : 1205 - 1212
  • [10] Angiotensin-(1-7), Adipokines and Inflammation
    Lelis, Deborah de Farias
    de Freitas, Daniela Fernanda
    Machado, Amanda Souto
    Crespo, Thaisa Soares
    Sousa Santos, Sergio Henrique
    METABOLISM-CLINICAL AND EXPERIMENTAL, 2019, 95 : 36 - 45