Sonochemical fabrication of reduction-responsive magnetic starch-based microcapsules

被引：13
|
作者：
Xu, Lifeng [1 ]
Zhong, Shuangling [2 ]
Shi, Chao [1 ]
Sun, Yuexin [1 ]
Zhao, Shengnan [1 ]
Gao, Yan [1 ]
Cui, Xuejun [1 ]
机构：
[1] Jilin Univ, Coll Chem, Changchun 130012, Jilin, Peoples R China
[2] Jilin Agr Univ, Coll Resources & Environm, Changchun 130118, Jilin, Peoples R China
来源：
ULTRASONICS SONOCHEMISTRY | 2018年 / 49卷
关键词：
Magnetic; microcapsules; Reductive-responsive; Sonochemical; Drug delivery; TARGETED DRUG-DELIVERY; CHITOSAN MICROCAPSULES; CONTROLLED-RELEASE; CELLULAR UPTAKE; NANOCAPSULES; GRAPHENE; PROTEIN; REDOX; SYSTEMS; NANOPARTICLES;
D O I：
10.1016/j.ultsonch.2018.07.047
中图分类号：
O42 [声学];
学科分类号：
070206 ; 082403 ;
摘要：
In this work, a novel, biocompatible, non-immunogenic and reductive-responsive magnetic starch-based microcapsules (RMSMCs) were designed and fabricated successfully via a facile sonochemical method for targeted delivery and triggered release of hydrophobic drugs. TEM image indicated that oleic acid (OA) modified Fe3O4 nanoparticles (OA-Fe3O4 NPs) were encapsulated into RMSMCs. The obtained RMSMCs were endowed with magnetism for drug targeted delivery because that the superparamagnetic OA-Fe3O4 NPs were encapsulated into RMSMCs. Moreover, Coumarin 6 (C6), a green fluorescent dye, was used as a model hydrophobic drug and loaded into RMSMCs. As drug carriers, the obtained spherical RMSMCs with the average size of 2 mu m presented excellent reductive-responsive release ability for hydrophobic drugs. Accordingly, the obtained RMSMCs would be promising carriers for targeted delivery and triggered release of hydrophobic drugs in biomedical applications.
引用
收藏
页码：169 / 174
页数：6
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