Screening for hepatitis B virus DNA in serum of organ donors and renal transplant recipients

被引：3

作者：

Miédougé, M

Rostaing, L

Mansuy, JM

Sandres-Sauné, K

Boudet, F

Izopet, J

机构：

[1] CHU Toulouse, Hop Purpan, Virol Lab, F-31059 Toulouse 9, France

[2] CHU Toulouse, Hop Rangueil, Unite Transplantat Organes, F-31403 Toulouse, France

[3] CHU Toulouse, Hop Purpan, Coordinat Prelevements Organes, F-31403 Toulouse 9, France

来源：

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 2003年 / 22卷 / 04期

关键词：

D O I：

10.1007/s10096-003-0889-3

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

In order to determine the impact of screening potential organ donors for hepatitis B virus DNA using a standardized test, the serum of 145 donor candidates was tested. All of the candidates were negative for hepatitis B virus DNA, but the status of one donor was doubtful for hepatitis B virus surface antigen and seven donors tested positive for hepatitis B virus core antibody without hepatitis B virus surface antigen. Nine transplant recipients tested positive for hepatitis B virus surface antibody; they were given kidneys from the donor with a doubtful hepatitis B virus surface antigen result and from four of the seven donors who tested positive for hepatitis B core antibody. Follow-up revealed no case of hepatitis B transmission. In this study, screening for hepatitis B virus DNA was useful and did not lead to donor organ shortage. Patients with hepatitis B virus surface antibodies can safely be given kidneys from donors who are positive for hepatitis B core antibody but negative for hepatitis B virus DNA.

引用

页码：246 / 248

页数：3

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