Platelet aggregation in patients with hypertrophic cardiomyopathy

Aim. To examine correlation between platelet aggregation and the degree of left ventricular hypertrophy (LVH) in patients with hypertrophic cardiomyopathy (HC). Material and methods. Routine clinical examination, ECG, echo-CG, measurement of platelet aggregation, routine biochemical blood tests were made in 45 HC males and 15 healthy controls. Results. HC patients were characterized with high induced and spontaneous platelet aggregation which increased with left ventricular myocardial mass. In LVH, platelets were especially sensitive to the aggregation inductor U-46619, thromboxane A(2) analogue. Conclusion. It is demonstrated that ther is a positive correlation between platelet aggregation and the degree of LVH in HC patients.