Differential pulse cathodic voltammetric determination of floctafenine and metopimazine

被引：7
|
作者：
Gazy, Azza A. [1 ]
Hassan, Ekram M. [1 ]
Abdel-Hay, Mohamed H. [1 ]
Belal, Tarek S. [1 ]
机构：
[1] Univ Alexandria, Fac Pharm, Dept Pharmaceut Analyt Chem, Alexandria, Egypt
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2007年 / 43卷 / 04期
关键词：
floctafenine; metopimazine; differential-pulse; voltammetric determination; HMDE;
D O I：
10.1016/j.jpba.2006.11.006
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A simple, rapid and sensitive voltammetric method for the determination of floctafenine (FFN) and metopimazine (MPZ) was developed. Well-defined cathodic waves were obtained for both drugs in Britton-Robinson buffer pH 9.0 using the differential-pulse mode at the hanging mercury drop electrode (HMDE). The current-concentration relationship was found to be linear over the ranges 0.4-3.6 and 0.4-2.4 mu g ml(-1) for FFN and MPZ, respectively. The quantification of the two drugs in their pharmaceutical formulations was carried out using the proposed voltammetric method and compared with spectrophotometric analysis data. The mechanisms of the electrode reactions for the two drugs were proposed. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码：1535 / 1539
页数：5
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