RETRACTED: Long non-coding RNA TTN-AS1 promotes the metastasis in breast cancer by epigenetically activating DGCR8 (Retracted Article)

被引：10
|
作者：
Qiu, P. [1 ]
Dou, Y. [2 ]
Ma, L-Z [2 ]
Tang, X-X [1 ]
Liu, X-L [2 ]
Chen, J-W [2 ]
机构：
[1] Xingtai Peoples Hosp, Dept Med Oncol, Xingtai, Peoples R China
[2] Xingtai Peoples Hosp, Dept Pathol, Xingtai, Peoples R China
来源：
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES | 2019年 / 23卷 / 24期
关键词：
Long non-coding RNA; TTN-AS1; BC; DGCR8; PROLIFERATION; PROGRESSION; STATISTICS;
D O I：
10.26355/eurrev_201912_19787
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
OBJECTIVE: Breast cancer (BC) is one of the most common fatal cancers. Recent studies have identified the vital roles of long non-coding RNAs (lncRNAs) in the development and progression of BC. This research aimed to investigate the underlying mechanisms of lncRNA TTN-AS1 in the metastasis of BC. PATIENTS AND METHODS: TTN-AS1 expression of tissues was detected by Real Time-quantitative Polymerase Chain Reaction (RT-qPCR) in 50 BC patients. Wound healing assay and transwell assay were used to observe the phenotypic alteration of BC cells after knockdown or overexpression of TTN-AS1. Moreover. RT-qPCR and Western blot assay were performed to discover the potential targets of TTN-AS1 in BC. RESULTS: TTN-AS1 expression in BC samples was significantly higher than that of the adjacent tissues. Besides, the migration and invasion of BC cells were markedly inhibited after TTN-AS1 was silenced, while promoted after TTN-AS1 overexpression. In addition, a remarkable decrease of DGCR8 was observed after TTN-AS1 was inhibited in BC cells. while DGCR8 was upregulated after overexpression of TTN-AS1. Furthermore, DGCR8 expression showed significant enhancement in BC tissues and was positively associated with TTN-AS1 level. CONCLUSIONS: Our study uncovered a new oncogene in BC and suggested that TTN-AS1 could enhance BC cell migration and invasion via sponging DGCR8, which provided a novel therapeutic target for the treatment of breast cancer.
引用
收藏
页码：10835 / 10841
页数：7
相关论文
共 50 条
  • [1] RETRACTED: Long noncoding RNA TUG1 promotes progression via upregulating DGCR8 in prostate cancer (Retracted Article)
    Yang, X-L
    Wei, C.
    Zhang, Y-B
    Guo, H-Q
    EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2019, 23 (06) : 2391 - 2398
  • [2] RETRACTED: Long non-coding RNA PVT1 facilitates cell proliferation by epigenetically regulating FOXF1 in breast cancer (Retracted Article)
    Guo, Guangcheng
    Wang, Fang
    Han, Mingli
    Gu, Yuanting
    Duan, Xin
    Li, Lin
    RSC ADVANCES, 2018, 8 (05) : 2740 - 2750
  • [3] RETRACTED: Long non-coding RNA TTN-AS1 promotes breast cancer cell migration and invasion via sponging miR-140-5p (Retracted article. See vol. 20, 2020)
    Xue, Jie
    Zhang, Zhixia
    Li, Xiaona
    Ren, Qingfang
    Wang, Qinghua
    ONCOLOGY LETTERS, 2020, 19 (02) : 1255 - 1260
  • [4] RETRACTED: Human MALAT-1 long non-coding RNA is overexpressed in cervical cancer metastasis and promotes cell proliferation, invasion and migration (Retracted Article)
    Zhang, Yan
    Wang, Tao
    Huang, Hua-Qiao
    Li, Wei
    Cheng, Xiao-Ling
    Yang, Jing
    JOURNAL OF BUON, 2015, 20 (06): : 1497 - 1503
  • [5] RETRACTED: Long noncoding RNA MIAT acts as an oncogene in Wilms' tumor through regulation of DGCR8 (Retracted Article)
    Zhao, X-S
    Tao, N.
    Zhang, C.
    Gong, C-M
    Dong, C-Y
    EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2019, 23 (23) : 10257 - 10263
  • [6] RETRACTED: Long non-coding RNAs in cervical cancer (Retracted Article)
    Arredondo-Robles, A. V.
    Rodriguez-Lopez, K. P.
    Avila-Aviles, R. D.
    JOURNAL OF APPLIED GENETICS, 2020, 61 (03) : 405 - 405
  • [7] Targeting Long Non-Coding RNA TTN-AS1 Suppresses Bladder Cancer Progression
    Xiao, Huiyuan
    Huang, Wen
    Li, Yanlei
    Zhang, Rongxin
    Yang, Long
    FRONTIERS IN GENETICS, 2021, 12
  • [8] RETRACTED: Long non-coding RNA OR3A4 promotes metastasis of ovarian cancer via inhibiting KLF6 (Retracted Article)
    Guo, F-F
    Jiang, M-M
    Hong, L-L
    Qiao, B.
    Lin, X-M
    Xu, W-Y
    Fu, X-Q
    EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2019, 23 (06) : 2360 - 2365
  • [9] RETRACTED: Long non-coding RNA ROR1-AS1 enhances colorectal cancer metastasis by targeting miR-375 (Retracted Article)
    Wang, F-Z
    Zhang, M-Q
    Zhang, L.
    Zhang, M-C
    EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2019, 23 (16) : 6899 - 6905
  • [10] RETRACTED: Critical role for the long non-coding RNA AFAP1-AS1 in the proliferation and metastasis of hepatocellular carcinoma (Retracted Article)
    Lu, Xu
    Zhou, Chuang
    Li, Renfeng
    Liang, Zhiwei
    Zhai, Wenlong
    Zhao, Longshuan
    Zhang, Shuijun
    TUMOR BIOLOGY, 2016, 37 (07) : 9699 - 9707
12345