Regioselective Synthesis of Thieno[3,2-b]quinolones by Acylation/Two-Fold Buchwald-Hartwig Reactions

被引：9

作者：

Janke, Julia ^{[1
]}

Ehlers, Peter ^{[1
,2
]}

Villinger, Alexander ^{[1
]}

Langer, Peter ^{[1
,2
]}

机构：

[1] Univ Rostock, Inst Chem, Albert Einstein Str 3a, D-18059 Rostock, Germany

[2] Univ Rostock, Leibniz Inst Katalyse eV, A Einstein Str 29a, D-18059 Rostock, Germany

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 2019卷 / 43期

关键词：

Catalysis; Cyclization; Heterocycles; Palladium; Regioselectivity; DOUBLE N-ARYLATION; HETEROCYCLES; ACRIDONES;

D O I：

10.1002/ejoc.201901247

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A variety of thienoquinolones were synthesized from readily accessible thiophene derivatives by regioselective acylations and subsequent two-fold Buchwald-Hartwig-amination. This cyclization allows a convenient synthesis of biologically and pharmaceutically important thienoquinolones. Several thienoquinolones were synthesized in good to very good yields. The optical properties of the products were studied in detail.

引用

页码：7255 / 7263

页数：9

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