Effects of the association between APOE rs405509 polymorphisms and gene-environment interactions on hand grip strength among middle-aged and elderly people in a rural population in southern China

被引：2

作者：

He, Haoyu ^{[1
,2
]}

Lu, Huaxiang ^{[1
,3
]}

Liu, Shuzhen ^{[1
]}

Cai, Jiansheng ^{[1
]}

Tang, Xu ^{[1
]}

Mo, Chunbao ^{[1
]}

Xu, Xia ^{[1
]}

Chen, Quanhui ^{[1
]}

Xu, Min ^{[1
]}

Nong, Chuntao ^{[1
]}

Liu, Qiumei ^{[1
]}

Zhang, Junling ^{[1
]}

Qin, Jian ^{[1
]}

Zhang, Zhiyong ^{[1
,4
]}

机构：

[1] Guangxi Med Univ, Sch Publ Hlth, 22 Shuangyong Rd, Nanning, Guangxi Zhuang, Peoples R China

[2] Guangxi Med Univ, Affiliated Hosp Stomatol, Dept Qual Management, 10 Shuangyong Rd, Nanning, Guangxi Zhuang, Peoples R China

[3] Guangxi Zhuang Autonomous Reg Ctr Dis Control & P, Dept Guangxi Sci & Technol Major Project, 18 Jinzhou Rd, Nanning, Guangxi Zhuang, Peoples R China

[4] Guilin Med Univ, Sch Publ Hlth, 20 Lequn Rd, Guilin, Guangxi Zhuang, Peoples R China

来源：

JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH | 2021年 / 16卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Hand grip strength; Apolipoprotein E; Single nucleotide polymorphism; Gene-environment interaction; APOLIPOPROTEIN-E; ALZHEIMERS-DISEASE; COGNITIVE FUNCTION; PHYSICAL FUNCTION; TOBACCO SMOKING; OUTCOMES; MORTALITY; FRACTURE; DENSITY; DECLINE;

D O I：

10.1186/s13018-021-02522-2

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Background Hand grip strength is a complex phenotype. The current study aimed to identify the effects of the association between APOE rs405509 polymorphisms and gene-environment interactions on hand grip strength among middle-aged and elderly people in a rural population in Gongcheng, southern China. Methods APOE rs405509 polymorphisms in 1724 participants (695 men and 1029 women, aged 45-97 years old) were genotyped using the Sequenom MassARRAY platform. Statistical analysis was conducted using SPSS 21.0 and Plink 1.90. Results The APOE rs405509 G allele was associated with lower hand grip strength in all participants (beta = -1.04, P value <0.001), and the correlation seemed to be even stronger among women. A significant gene-environment interaction was observed between APOE rs405509 and smoking, especially in men. The hand grip strength of male smokers carrying the GG genotype was significantly higher than that of nonsmokers (P value = 0.004). Conclusions APOE rs405509 polymorphisms might be genetic factors that affect hand grip strength in a rural population in Gongcheng, southern China. The APOE rs405509-smoking interaction has an impact on hand grip strength.

引用

页数：7

共 4 条

[1] Effects of the association between APOE rs405509 polymorphisms and gene-environment interactions on hand grip strength among middle-aged and elderly people in a rural population in southern China
Haoyu He
Huaxiang Lu
Shuzhen Liu
Jiansheng Cai
Xu Tang
Chunbao Mo
Xia Xu
Quanhui Chen
Min Xu
Chuntao Nong
Qiumei Liu
Junling Zhang
Jian Qin
Zhiyong Zhang
Journal of Orthopaedic Surgery and Research, 16
[2] ASSOCIATION BETWEEN HAND GRIP STRENGTH, SARCOPENIA AND ARTHRITIS AMONG MIDDLE-AGED AND ELDERLY CHINESE POPULATION:A STRATIFIED CROSS-SECTIONAL STUDY
Chen, Y.
Xue, Y.
Jiang, D.
Li, M.
Deng, Z.
Pang, J.
Zhan, H.
Zheng, Y.
Cao, Y.
OSTEOARTHRITIS AND CARTILAGE, 2021, 29 : S71 - S71
[3] Association of handgrip strength with hypertension among middle-aged and elderly people in Southern China: A cross-sectional study
Zhang, Xiaoxia
Huang, Lingling
Peng, Xin
Xie, Yixian
Bao, Xinyu
Huang, Junxuan
Wang, Peixi
CLINICAL AND EXPERIMENTAL HYPERTENSION, 2020, 42 (02) : 190 - 196
[4] Association Between Muscle Strength and Cystatin C-Based Estimated Glomerular Filtration Rate Among Middle-Aged and Elderly Population: Findings Based on the China Health and Retirement Longitudinal Study (CHARLS), 2015
Zhou, Weiran
Zhou, Huili
Zhao, Shuan
Li, Yang
Shi, Yiqin
Ding, Xiaoqiang
INTERNATIONAL JOURNAL OF GENERAL MEDICINE, 2021, 14 : 3059 - 3067

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