SYNTHESIS AND PHARMACOLOGICAL ACTIVITY OF 3-(2,2,2-TRICHLORO-1-HYDROXYETHYL)IMIDAZO [1,2-a]BENZIMIDAZOLE DIHYDROCHLORIDES

被引：13

作者：

Anisimova, V. A. ^{[1
]}

Spasov, A. A. ^{[2
,3
,4
]}

Kosolapov, V. A. ^{[2
]}

Tolpygin, I. E. ^{[1
]}

Porotikov, V. I.

Kucheryavenko, A. F.

Sysoeva, V. A. ^{[2
]}

Tibir'kova, E. V. ^{[2
]}

El'tsova, L. V. ^{[2
]}

机构：

[1] So Fed Univ, Res Inst Phys & Organ Chem, Rostov Na Donu, Russia

[2] Volgograd State Med Univ, Pharmacol Res Inst, Volgograd, Russia

[3] Russian Acad Med Sci, Volgograd Sci Ctr, Volgograd, Russia

[4] Volgograd Reg Adm, Volgograd, Russia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2009年 / 43卷 / 09期

关键词：

synthesis; imidazo[1,2-a]benzimidazoles; trichloroethanols; spasmolytic action; antiaggregant activity; radioprotective properties; antiarrhythmic activity; DERIVATIVES;

D O I：

10.1007/s11094-009-0340-x

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Aseries of 3-(2,2,2-trichloro-1-hydroxyethyl)imidazo[1,2-a]benzimidazole dihydrochlorides have been synthesized and their pharmacological properties have been studied. It is established that the synthesized compounds exhibit weak antioxidant activity. In addition, they possess platelet and erythrocyte antiaggregant properties, show pronounced spasmolytic action, and have low toxicity. Some of them also exhibit antiradiomimetic, hypotensive, and antiarrhythmic properties.

引用

页码：491 / 494

页数：4

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