Vitamin D-binding protein and its polymorphisms as a predictor for metabolic syndrome

被引：11
|
作者：
Karuwanarint, Piyaporn [1 ]
Phonrat, Benjaluck [2 ]
Tungtrongchitr, Anchalee [3 ]
Suriyaprom, Kanjana [4 ]
Chuengsamarn, Somlak [5 ]
Schweigert, Florian J. [6 ]
Tungtrongchitr, Rungsunn [1 ]
机构：
[1] Mahidol Univ, Fac Trop Med, Dept Trop Nutr & Food Sci, Bangkok, Thailand
[2] Mahidol Univ, Fac Trop Med, Dept Clin Trop Med, Bangkok, Thailand
[3] Mahidol Univ, Fac Med, Dept Parasitol, Siriraj Hosp, Bangkok, Thailand
[4] Rangsit Univ, Fac Med Technol, Pathum Thani, Thailand
[5] Srinakharinwirot Univ, HRH Princess Maha Chakri Sirindhorn Med Ctr, Fac Med, Div Endocrinol & Metab, Nakornnayok, Thailand
[6] Univ Potsdam, Inst Nutr Sci, Dept Physiol & Pathophysiol Nutr, Potsdam, Germany
来源：
BIOMARKERS IN MEDICINE | 2018年 / 12卷 / 05期
关键词：
GC gene; GC-globulin; metabolic syndrome; polymorphism; Thai population; vitamin D-binding protein; TYPE-2; DIABETES-MELLITUS; DBP GENE POLYMORPHISM; 25-HYDROXYVITAMIN D; INSULIN-RESISTANCE; D LEVEL; ASSOCIATION; GC; OBESITY; WOMEN; SUSCEPTIBILITY;
D O I：
10.2217/bmm-2018-0029
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Aim: To investigate the relationship of vitamin D-binding protein (GC) and genetic variation of GC (rs4588, rs7041 and rs2282679) with metabolic syndrome (MetS) in the Thai population. Materials & methods: GCglobulin concentrations were measured by quantitative western blot analysis in 401 adults. All participants were genotyped using TaqMan allelic discrimination assays. Results: GC-globulin levels were significatly lower in MetS subjects than in control subjects, in which significant negative correlations of GC-globulin levels with systolic blood pressure, glucose and age were found. Male participants who carried the GT genotype for rs4588 showed an increased risk of MetS compared with the GG wild-type (odds ratio: 3.25; p = 0.004). Conclusion: GC-globulin concentrations and variation in GC rs4588 were supported as a risk factor for MetS in Thais.
引用
收藏
页码：465 / 473
页数：9
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