Artifacts in optical projection tomography due to refractive-index mismatch: model and correction

被引：5
|
作者：
Liu, Yan [1 ]
Dong, Jonathan [1 ]
Schmidt, Cedric [2 ]
Boquet-Pujadas, Aleix [1 ]
Extermann, Jerome [2 ]
Unser, Michael [1 ]
机构：
[1] Ecole Polytech Fed Lausanne, Biomed Imaging Grp, Stn 17, CH-1015 Lausanne, Switzerland
[2] Univ Appl Sci Western Switzerland, HEPIA HES SO, Rue Prairie 4, CH-1202 Geneva, Switzerland
来源：
OPTICS LETTERS | 2022年 / 47卷 / 11期
基金：
欧洲研究理事会;
关键词：
RECONSTRUCTION;
D O I：
10.1364/OL.457144
中图分类号：
O43 [光学];
学科分类号：
070207 ; 0803 ;
摘要：
Optical projection tomography (OPT) is a powerful tool for three-dimensional (3D) imaging of mesoscopic samples. While it is able to achieve resolution of a few tens of microns over a sample volume of several cubic centimeters, the reconstructed images often suffer from artifacts caused by inaccurate calibration. In this work, we focus on the refractive-index mismatch between the sample and the surrounding medium. We derive a 3D cone-beam forward model of OPT that approximates the effect of refractive-index mismatch. We then implement a fast and efficient reconstruction method to correct for the induced seagull-shaped artifacts on experimental images of fluorescent beads. (C) 2022 Optica Publishing Group
引用
收藏
页码：2618 / 2621
页数：4
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