Development, Potential Anticancer Activity and the Receptor Profile of Different Functionalized 1,3,5-Triazine Derivatives

被引:9
|
作者
Sarhan, Mona O. [1 ]
Motaleb, Mohamed A. [1 ]
Ibrahim, Ismail T. [1 ]
Anwar, Manal M. [2 ]
Zaghary, Wafaa. A. [3 ]
机构
[1] Egyptian Atom Energy Author, Labeled Compound Dept, POB 13759, Cairo, Egypt
[2] Natl Res Ctr, Dept Therapeut Chem, Cairo 12622, Egypt
[3] Helwan Univ, Dept Pharmaceut Chem, Coll Pharm, Cairo 11795, Egypt
关键词
Anticancer; enzymes; molecular docking; synthetic methods; 1,3,5-triazines; anti-protozoals; DNA METHYLTRANSFERASE INHIBITORS; HSP90 MOLECULAR CHAPERONE; PHOSPHATIDYLINOSITOL 3-KINASE INHIBITOR; IN-VIVO FUNCTION; PHOSPHOINOSITIDE; 3-KINASE; CRYSTAL-STRUCTURE; GENE-EXPRESSION; PI3K INHIBITOR; CANCER-CELLS; PATHWAY;
D O I
10.2174/1389557517666170927160256
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
1,3,5-Triazine-based compounds form a privileged class of compounds in the medicinal chemistry field as they are versatile synthetic scaffolds possessing wide spectra of biological effects including potential anticancer activity. 1,3,5-Triazine compounds explored for anticancer activities have been reported to act by various mechanisms on several molecular targets in human cells such as methyltransferase (DNMT), heat shock protein 90 (Hsp90) and phosphoinositide 3-kinase (PI3K). This review focuses on the synthetic strategies for current developments of 1,3,5-triazine-based anticancer agents and discuses the docking studies that confirm their unique binding modes in the targeted receptors active sites. This article also aims to highlight the future directions for the easy access to these frameworks of more potent and specific anticancer activity.
引用
收藏
页码:1302 / 1320
页数:19
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