SARS-CoV-2 tracking in Tunisia through next-generation sequencing: lessons for the future

被引：2
|
作者：
Rebai, Ahmed [1 ]
Souissi, Amal [1 ]
Abid, Nabil [2 ]
Masmoudi, Saber [1 ]
机构：
[1] Univ Sfax, Ctr Biotechnol Sfax, Lab Mol & Cellular Screening Proc, POB 1177, Sfax 3018, Tunisia
[2] Univ Monastir, Fac Pharm, Lab Transmissible Dis & Biol Active Subst, Monastir 5000, Tunisia
来源：
EURO-MEDITERRANEAN JOURNAL FOR ENVIRONMENTAL INTEGRATION | 2021年 / 6卷 / 02期
关键词：
COVID-19; SARS-CoV-2; Genome; Lineage; Coronavirus;
D O I：
10.1007/s41207-021-00254-7
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
In this study, data available from GISAID on the whole-genome sequences of SARS-CoV-2 variants circulating in Tunisia were analyzed, and the prevalences of those variants in Tunisia were compared to their prevalences in other North African countries and around the world. Our results show new mutations and different prevalences of some lineages. In particular, new sets of mutations were identified in the spike protein of the virus during the analysis of 85 Tunisian samples, and the lineage B1.160 was found to be the most prevalent (18%) lineage in Tunisia. The prevalence of this lineage in Tunisia was significantly higher than its prevalence worldwide and in samples from neighboring countries (3%). This preliminary study shows the importance of tracking virus variants by next-generation sequencing in order to assess the dynamics of the COVID-19 pandemic and the impact of vaccination on the evolution of the virus.
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页数：5
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