Copper-Catalyzed Cascade Cyclization Reaction of Enamines and Electron-Deficient Terminal Alkynes: Synthesis of Polysubstituted Pyrido[1,2-a]indoles

被引：34

作者：

Liu, Pei ^{[1
]}

Yang, Ming ^{[1
]}

Gong, Yue ^{[1
]}

Yu, Yang ^{[1
]}

Zhao, Yu-Long ^{[1
]}

机构：

[1] Northeast Normal Univ, Fac Chem, Jilin Prov Key Lab Organ Funct Mol Design & Synth, Changchun 130024, Jilin, Peoples R China

来源：

ORGANIC LETTERS | 2020年 / 22卷 / 01期

关键词：

C-H; EFFICIENT SYNTHESIS; AZOMETHINE YLIDES; ACCESS; METAL; HETEROCYCLES; ANNULATION; ALKALOIDS; STRATEGY; PYRROLES;

D O I：

10.1021/acs.orglett.9b03739

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel copper-catalyzed cascade cyclization reaction between enamines and electron-deficient terminal alkynes has been developed. The reaction provides a new and efficient strategy for the construction of polysubstituted pyrido[1,2-a]indoles by the formation of two rings, three C-C bonds, and one C-N bond in a single step from readily available acyclic starting materials.

引用

页码：36 / 40

页数：5

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