Effects of isoflurane, sevoflurane and methoxyflurane on the electroencephalogram of the chicken

被引:12
|
作者
McIlhone, Amanda E. [1 ]
Beausoleil, Ngaio J. [1 ]
Johnson, Craig B. [1 ]
Mellor, David J. [1 ]
机构
[1] Massey Univ, Inst Vet Anim & Biomed Sci, Anim Welf Sci & Bioeth Ctr, Palmerston North 4442, New Zealand
关键词
anaesthesia; burst suppression; chicken; EEG; frequency analysis; MINIMUM ANESTHETIC CONCENTRATION; BISPECTRAL INDEX; HALOTHANE ANESTHESIA; SLEEP HOMEOSTASIS; DOSE-RESPONSE; BRAIN; BIRDS; MAMMALS; RAT; REQUIREMENTS;
D O I
10.1111/vaa.12154
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
ObjectiveAnaesthetics have differing effects on mammalian electroencephalogram (EEG) but little is known about the effects on avian EEG. This study explored how inhalant anaesthetics affect chicken EEG. Study designExperimental study. AnimalsTwelve female Hyline Brown chickens aged 6-11weeks. MethodsEach chicken was anaesthetized with isoflurane, sevoflurane, and methoxyflurane. For each, anaesthesia was adjusted to 1, 1.5 and 2 times Minimum Anaesthetic Concentration (MAC). Total Power (Ptot), Median Frequency (F50), Spectral Edge Frequency (F95) and Burst Suppression Ratio (BSR) were calculated at each volume concentration. BSR data were analyzed using doubly repeated measures anova. Neither isoflurane nor sevoflurane could be included in analysis of F50, F95 and Ptot because of extensive burst suppression; Methoxyflurane data were analyzed using RM anova. ResultsThere was a significant interaction between anaesthetic and concentration on BSR [F(4,22)=10.65, p<0.0001]. For both isoflurane and sevoflurane, BSR increased with concentration. Isoflurane caused less suppression than sevoflurane at 1.5 MAC and at final 1 MAC while methoxyflurane caused virtually no burst suppression. Methoxyflurane concentration had a significant effect on F50 [F(2,20)=3.83, p=0.04], F95 [F(2,20)=4.03, p=0.03] and Ptot [F(2,20)=5.22, p=0.02]. Decreasing methoxyflurane from 2 to 1 MAC increased F50 and F95. Ptot increased when concentration decreased from 1.5 to 1 MAC and tended to be higher at 1 MAC than at 2 MAC. Conclusions and Clinical relevanceIsoflurane and sevoflurane suppressed chicken EEG in a dose-dependent manner. Higher concentrations of methoxyflurane caused an increasing degree of synchronization of EEG. Isoflurane and sevoflurane suppressed EEG activity to a greater extent than did methoxyflurane at equivalent MAC multiples. Isoflurane caused less suppression than sevoflurane at intermediate concentrations. These results indicate the similarity between avian and mammalian EEG responses to inhalant anaesthetics and reinforce the difference between MAC and anaesthetic effects on brain activity in birds.
引用
收藏
页码:613 / 620
页数:8
相关论文
共 50 条
  • [1] Comparison of the effects of halothane, isoflurane and methoxyflurane on the electroencephalogram of the horse
    Johnson, CB
    Taylor, PM
    BRITISH JOURNAL OF ANAESTHESIA, 1998, 81 (05) : 748 - 753
  • [2] Comparative effects of halothane, isoflurane, sevoflurane and desflurane on the electroencephalogram of the rat
    Murrell, J. C.
    Waters, D.
    Johnson, C. B.
    LABORATORY ANIMALS, 2008, 42 (02) : 161 - 170
  • [3] Clinical effects of isoflurane and sevoflurane in lambs
    Vettorato, Enzo
    Schoeffmann, Gudrun
    Burke, John G.
    Gibson, Alastair J. N.
    Clutton, Eddie R.
    VETERINARY ANAESTHESIA AND ANALGESIA, 2012, 39 (05) : 495 - 502
  • [4] CARDIOVASCULAR EFFECTS OF SEVOFLURANE AND ISOFLURANE IN VOLUNTEERS
    MALAN, TP
    DINARDO, JA
    FRINK, EJ
    ISNER, RJ
    BROWN, EA
    ANESTHESIOLOGY, 1994, 81 (3A) : A131 - A131
  • [5] Effects of halothane on the electroencephalogram of the chicken
    McIlhone, Amanda E.
    Beausoleil, Ngaio J.
    Kells, Nikki J.
    Johnson, Craig B.
    Mellor, David J.
    VETERINARY MEDICINE AND SCIENCE, 2018, 4 (02): : 98 - 105
  • [6] Comparison of the effects of halothane and isoflurane on the electroencephalogram of the horse
    Johnson, CB
    Taylor, PM
    BRITISH JOURNAL OF ANAESTHESIA, 1996, 77 (05) : P689 - P689
  • [7] The Effects of Sevoflurane and Isoflurane in Nasal Septal Surgery
    Ozkiris, Mahmut
    Kapusuz, Zeliha
    Ozturk, Sureyya
    Bolat, Esef
    Saydam, Levent
    JOURNAL OF CRANIOFACIAL SURGERY, 2013, 24 (04) : 1376 - 1379
  • [8] The differential effects of isoflurane and sevoflurane on neonatal mice
    Zhao, Shuai
    Fan, Ziqi
    Hu, Jing
    Zhu, Yueli
    Lin, Caixiu
    Shen, Ting
    Li, Zheyu
    Li, Kaicheng
    Liu, Zhirong
    Chen, Yanxing
    Zhang, Baorong
    SCIENTIFIC REPORTS, 2020, 10 (01)
  • [10] The effects of age, isoflurane and sevoflurane on atracurium in lambs
    Schoeffmann, Gudrun
    Vettorato, Enzo
    Burke, John G.
    Gibson, Alastair J. N.
    Clutton, Eddie R.
    VETERINARY ANAESTHESIA AND ANALGESIA, 2012, 39 (03) : 256 - 265