New dimensions of the virus world discovered through metagenomics

被引:212
|
作者
Kristensen, David M. [2 ]
Mushegian, Arcady R. [2 ,3 ]
Dolja, Valerian V. [4 ,5 ]
Koonin, Eugene V. [1 ]
机构
[1] NIH, Natl Ctr Biotechnol Informat, Bethesda, MD 20894 USA
[2] Stowers Inst Med Res, Kansas City, MO 64110 USA
[3] Univ Kansas, Med Ctr, Dept Microbiol Mol Genet & Immunol, Kansas City, KS 66160 USA
[4] Oregon State Univ, Dept Bot & Plant Pathol, Corvallis, OR 97331 USA
[5] Oregon State Univ, Ctr Genome Res & Biocomp, Corvallis, OR 97331 USA
关键词
STRANDED RNA VIRUSES; TRANSFER AGENT GENES; LARGE DNA VIRUSES; EVOLUTIONARY GENOMICS; VIRAL METAGENOMICS; MARINE VIRUSES; SARGASSO SEA; MIMIVIRUS; SEQUENCES; COMMUNITIES;
D O I
10.1016/j.tim.2009.11.003
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Metagenomic analysis of viruses suggests novel patterns of evolution, changes the existing ideas of the composition of the virus world and reveals novel groups of viruses and virus-like agents. The gene composition of the marine DNA virome is dramatically different from that of known bacteriophages. The virome is dominated by rare genes, many of which might be contained within virus-like entities such as gene transfer agents. Analysis of marine metagenomes thought to consist mostly of bacterial genes revealed a variety of sequences homologous to conserved genes of eukaryotic nucleocytoplasmic large DNA viruses, resulting in the discovery of diverse members of previously undersampled groups and suggesting the existence of new classes of virus-like agents. Unexpectedly, metagenomics of marine RNA viruses showed that representatives of only one superfamily of eukaryotic viruses, the picorna-like viruses, dominate the RNA virome.
引用
收藏
页码:11 / 19
页数:9
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