Alkylation of Heteroaryl Chlorides through Homolytic Aromatic Substitution by Alkyl Radicals Derived from Alkyl Formates

被引：1
|
作者：
Ikeda, Yuko [1 ]
Mandai, Tomoya [1 ]
Yonekura, Kyohei [1 ]
Shirakawa, Eiji [1 ]
机构：
[1] Kwansei Gakuin Univ, Sch Sci & Technol, Dept Appl Chem Environm, 2-1 Gakuen, Sanda, Hyogo 6691337, Japan
来源：
CHEMISTRY LETTERS | 2021年 / 50卷 / 05期
关键词：
Alkylation; Alkyl formates; Radical mechanism; ALDEHYDES; ALKANES;
D O I：
10.1246/cl.210015
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The alkylation of heteroaryl chlorides through a homolytic aromatic substitution (HAS) mechanism was achieved by the use of alkyl formates as alkylating agents in the presence of a tert-butoxy radical precursor, where alkyl radicals are generated from alkyl formates through hydrogen abstraction followed by beta-scission with decarboxylation.
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页码：1006 / 1010
页数：5
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