Relatedness testing in subdivided populations

被引：46
|
作者：
Ayres, KL [1 ]
机构：
[1] Univ Reading, Dept Appl Stat, Reading RG6 6FN, Berks, England
来源：
FORENSIC SCIENCE INTERNATIONAL | 2000年 / 114卷 / 02期
关键词：
paternity index; likelihood ratio; population substructure; coancestry coefficient F-ST;
D O I：
10.1016/S0379-0738(00)00289-9
中图分类号：
DF [法律]; D9 [法律]; R [医药、卫生];
学科分类号：
0301 ; 10 ;
摘要：
Assigning probabilities to alleged relationships, given DNA profiles, requires, among other things, calculation of a likelihood ratio (LR). Such calculations usually assume independence of genes: this assumption is not appropriate when the tested individuals share recent ancestry due to population substructure. Adjusted LR formulae, incorporating the coancestry coefficient F-ST, are presented here fur various two-person relationships, and the issue of mutations in parentage testing is also addressed, (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
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页码：107 / 115
页数：9
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