Intramolecular weak hydrogen bonds in substituted 4-arylthiazoles

We have synthesized new polysubstituted 4-arylthiazoles with a substitution pattern able to form intramolecular weak hydrogen bonds as secondary structure, and besides, displaying in the aromatic region of their H-1-NMR spectra an ABX spin system and only one singlet (the thiazolic proton), thus permitting us to make doubtless assignments. These results confirmed previous assignments made by us in other thiazole-derivatives prepared by the first time. ne spectroscopic data (IR, H-1-NMR and MS) of these thiazoles, as well as of the required intermediates, are discussed.