Synthesis of 2-substituted bamipine derivatives

被引：2
|
作者：
Weis, R [1 ]
Seebacher, W [1 ]
机构：
[1] Graz Univ, Inst Pharmaceut Chem & Pharmaceut Technol, A-8010 Graz, Austria
来源：
TETRAHEDRON | 2003年 / 59卷 / 09期
关键词：
anilinopiperidines; antibacterials; bamipine; hydrogenation; piperidines; stereoisomerism;
D O I：
10.1016/S0040-4020(03)00082-6
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
2-Substituted derivatives of bamipine and its 1-phenyl analogue have been prepared in several steps from dihydropyridine-2(1H)-thiones. The configurations and the conformations of the formed diastereoisomers have been investigated by NMR spectroscopy. The antimycobacterial activities of the title compounds have been examined. (C) 2003 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1395 / 1402
页数：8
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