Impact of immune checkpoint protein expression in tumor cells and tumor infiltrating CD8+ T cells on clinical benefit from PD-1 blockade in metastatic clear cell renal cell carcinoma (mccRCC).

被引：1
|
作者：
Pigeon, Jean-Christophe
Jegede, Opeyemi
Mahoney, Kathleen M.
Moreira, Raphael Brandao
Novak, Jesse
Conen, Hilla
机构：
来源：
JOURNAL OF CLINICAL ONCOLOGY | 2017年 / 35卷 / 06期
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
477
引用
收藏
页数：1
相关论文
共 50 条
  • [1] Exhausted status of tumor-infiltrating CD8 T Cells determine their response to PD-1 blockade in ovarian clear cell carcinoma
    Park, Junsik
    Kim, Jung Chul
    Lee, Miran
    Lee, JooHyang
    Lee, Yu Sang
    Lee, Yong Jae
    Kim, Sunghoon
    Kim, Sang Wun
    Lee, Jung-Yun
    GYNECOLOGIC ONCOLOGY, 2023, 176 : S299 - S299
  • [2] Activity of cabozantinib (cabo) after PD-1/PD-L1 immune checkpoint blockade (ICB) in metastatic clear cell renal cell carcinoma (mccRCC)
    McGregor, B. A.
    Lalani, A-K.
    Xie, W.
    Steinharter, J. A.
    Martini, D. J.
    Nuzzo, P. V.
    Chanza, N. Martinez
    Harshman, L. C.
    Bilen, M. A.
    Choueiri, T. K.
    ANNALS OF ONCOLOGY, 2018, 29
  • [3] Association of human endogenous retrovirus (hERV) expression with clinical efficacy of PD-1 blockade in metastatic clear cell renal cell carcinoma (mccRCC).
    Pignon, Jean-Christophe
    Jegede, Opeyemi
    Shukla, Sachet A.
    Braun, David A.
    Horak, Christine
    Wind-Rotolo, Megan
    Ishii, Yuko
    Catalano, Paul J.
    Freeman, Gordon J.
    Jennings, Rebecca B.
    De Cubas, Aguirre
    Rathmell, Kimryn
    Choueiri, Toni K.
    Atkins, Michael B.
    McDermott, David F.
    Signoretti, Sabina
    JOURNAL OF CLINICAL ONCOLOGY, 2019, 37 (15)
  • [4] Tumor-infiltrating CD8+ T cells recognize a heterogeneously expressed functional neoantigen in clear cell renal cell carcinoma
    Masahiro Matsuki
    Yoshihiko Hirohashi
    Munehide Nakatsugawa
    Aiko Murai
    Terufumi Kubo
    Shinichi Hashimoto
    Serina Tokita
    Kenji Murata
    Takayuki Kanaseki
    Tomohide Tsukahara
    Sachiyo Nishida
    Toshiaki Tanaka
    Hiroshi Kitamura
    Naoya Masumori
    Toshihiko Torigoe
    Cancer Immunology, Immunotherapy, 2022, 71 : 905 - 918
  • [5] Tumor-infiltrating CD8+ T cells recognize a heterogeneously expressed functional neoantigen in clear cell renal cell carcinoma
    Matsuki, Masahiro
    Hirohashi, Yoshihiko
    Nakatsugawa, Munehide
    Murai, Aiko
    Kubo, Terufumi
    Hashimoto, Shinichi
    Tokita, Serina
    Murata, Kenji
    Kanaseki, Takayuki
    Tsukahara, Tomohide
    Nishida, Sachiyo
    Tanaka, Toshiaki
    Kitamura, Hiroshi
    Masumori, Naoya
    Torigoe, Toshihiko
    CANCER IMMUNOLOGY IMMUNOTHERAPY, 2022, 71 (04) : 905 - 918
  • [6] Prognostic impact of immune gene expression signature and tumor infiltrating immune cells in localized clear cell renal cell carcinoma
    Ghatalia, Pooja
    Gordetsky, Jennifer
    Kuo, Fengshen
    Dulaimi, Essel
    Cai, Kathy Q.
    Deyarajan, Karthik
    Bae, Sejong
    Naik, Gurudatta
    Chan, Timothy A.
    Uzzo, Robert
    Hakimi, A. Ari
    Sonpavde, Guru
    Plimack, Elizabeth
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2019, 7
  • [7] Tumor immune microenvironment determinants of response to lenvatinib and a PD-1 blockade in clear cell renal cell carcinoma
    Vuong, Lynda
    Kuo, Fengshen
    Jiang, Hui
    Mascareno, Eduardo A.
    Rappold, Phillip
    Sabio, Erich
    Weiss, Kate
    Cornish, Andrew
    Reese, Stephen
    Adlesic, Mojca
    Solit, David
    Frew, Ian
    Akin, Oguz
    Chen, Yingbei
    Li, Ming O.
    Chan, Timothy A.
    Hakimi, Ari A.
    CANCER RESEARCH, 2023, 83 (16)
  • [8] Fibroblast activation protein (FAP)-targeted radiotherapy increases tumor CD8+ T cell infiltration and enhances response to PD-1 immune checkpoint blockade
    Zboralski, Dirk
    Hohne, Aileen
    Christensen, Esben
    Paschke, Matthias
    Robillard, Liliane
    Simmons, Andrew D.
    Osterkamp, Frank
    Harding, Thomas C.
    Nguyen, Minh
    CANCER RESEARCH, 2023, 83 (07)
  • [9] Combined blockade of TGF-β and PD-1 restores the function of tumor-infiltrating CD8+ T cells in glioblastoma
    Kim, A. R.
    Park, J.
    Kang, S-G.
    Moon, J. H.
    Kim, E. H.
    Park, S-H.
    Chang, J. H.
    Shin, E-C.
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2019, 49 : 1733 - 1733
  • [10] Human breast tumor-infiltrating CD8+ T cells retain polyfunctionality despite PD-1 expression
    Colt A. Egelston
    Christian Avalos
    Travis Y. Tu
    Diana L. Simons
    Grecia Jimenez
    Jae Y. Jung
    Laleh Melstrom
    Kim Margolin
    John H. Yim
    Laura Kruper
    Joanne Mortimer
    Peter P. Lee
    Nature Communications, 9
12345