A Green Approach for the Synthesis of Silver Nanoparticle-Embedded Chitosan Bionanocomposite as a Potential Device for the Sustained Release of the Itraconazole Drug and Its Antibacterial Characteristics

被引：20

作者：

Saruchi ^{[1
]}

Kaur, Manpreet ^{[1
]}

Kumar, Vaneet ^{[2
]}

Ghfar, Ayman A. ^{[3
]}

Pandey, Sadanand ^{[4
]}

机构：

[1] CT Inst Pharmaceut Sci, Dept Biotechnol, Shahpur Campus, Jalandhar 144008, Punjab, India

[2] CT Inst Engn Management & Technol, Dept Appl Sci, Shahpur Campus, Jalandhar 144623, Punjab, India

[3] King Saud Univ, Coll Sci, Dept Chem, POB 2455, Riyadh 11451, Saudi Arabia

[4] Yeungnam Univ, Coll Nat Sci, Dept Chem, 280 Daehak Ro, Gyongsan 38541, Gyeongbuk, South Korea

来源：

POLYMERS | 2022年 / 14卷 / 09期

关键词：

Saccharum officinarum; silver nanoparticles; chitosan; bionanocomposite; antibacterial activity; NETWORK PARAMETERS; TRAGACANTH GUM; CROSS-LINKING; HYDROGEL; DELIVERY; ACID; COMBINATION; FABRICATION; REMOVAL;

D O I：

10.3390/polym14091911

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

The present research work intended to demonstrate the green synthesis of silver nanoparticles (AgNPs) using the plant extract Saccharum officinarum, and then the development of chitosan-silver (CH-Ag) bionanocomposite. The synthesized AgNPs were characterized using UV spectroscopy, Fourier transform infrared (FTIR), and transmission electron microscopy (TEM). The maximum absorption spectrum peak was observed at 420 nm, revealing the formation of AgNPs by the stem extract of S. officinarum. The AgNPs sizes were in the range of 10-50 nm. Itraconazole is an antifungal that is used as a novel drug to study its release through synthesized bionanocomposite. Different kinetic models, such as zero order, first order, Korsmeyer-Peppas, Hixson-Crowell and Higuchi, were used to study the drug release profile from the synthesized CH-Ag bionanocomposite. The first-order kinetic model showed the best fit for the drug release with the maximum regression coefficient value. The antibacterial activity of the synthesized CH-Ag bionanocomposite was examined against Bacillus cereus, Staphylococcus, and Escherichia coli, and it was shown to be efficient against these strains.

引用

页数：15

共 3 条

[1] Green silver nanoparticle-embedded chitosan-alginate hydrogel: A novel antibacterial approach for potential wound healing
Aldakheel, Fahad M.
Wickramasinghe, Ranil
Thamaraiselvan, Chidambaram
El Sayed, Marwa M.
Fagir, Mohammed H.
El Dein, Dalia K.
Mohsen, Dalia
POLYMERS & POLYMER COMPOSITES, 2025, 33
[2] Green synthesis of silver nanoparticle and silver based chitosan bionanocomposite using stem extract of Saccharum officinarum and assessment of its antibacterial activity
Paulkumar K.
Gnanajobitha G.
Vanaja M.
Pavunraj M.
Annadurai G.
Annadurai, Gurusamy (annananoteam@gmail.com), 1600, IOP Publishing Ltd (08):
[3] Green synthesis of silver nanoparticle using Oscillatoria sp. extract, its antibacterial, antibiofilm potential and cytotoxicity activity
Adebayo-Tayo, Bukola
Salaam, Adebayo
Ajibade, Adebola
HELIYON, 2019, 5 (10)

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