CATALYTIC ASYMMETRIC SYNTHESIS OF ESOMEPRAZOLE BY A TITANIUM COMPLEX WITH A HEXA-AZA-TRIPHENOLIC MACROCYCLE LIGAND

被引：9

作者：

Song, Weiguo ^{[1
,2
]}

Dong, Liangjun ^{[2
]}

Zhou, Yuhan ^{[2
,3
]}

Fu, Yongqiang ^{[2
]}

Xu, Wenfang ^{[1
]}

机构：

[1] Shandong Univ, Inst Med Chem, Sch Pharmaceut Sci, Jinan 250100, Peoples R China

[2] Shouguang Fukang Pharmaceut Co Ltd, Shouguang 262700, Peoples R China

[3] Dalian Univ Technol, Sch Pharmaceut Sci & Technol, State Key Lab Fine Chem, Dalian, Peoples R China

来源：

SYNTHETIC COMMUNICATIONS | 2015年 / 45卷 / 01期

关键词：

Asymmetric catalysis; chiral macrocycles; enantioselective sulfoxidation; esomeprazole; ACHIRAL-PHASE CHROMATOGRAPHY; PROTON-PUMP INHIBITOR; SELF-DISPROPORTIONATION; LANTHANIDE(III) COMPLEXES; ORGANIC FRAMEWORK; OXIDATION; SULFIDES; ENANTIOMERS; SULFOXIDATION; H2O2;

D O I：

10.1080/00397911.2014.952307

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthesis of esomeprazole via catalytic asymmetric oxidation of 1H-benzimidazolyl pyridinylmethyl sulfide by a titanium complex with a hexa-aza-triphenolic macrocycle ligand is described. Esomeprazole was prepared with 99.6% ee, which meets the high requirement of the European Pharmacopeia on enantiomeric purity.

引用

页码：70 / 77

页数：8

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