Rapid Spreading and Immune Evasion by Vaccinia Virus

被引：2
|
作者：
Smith, Geoffrey L. [1 ]
机构：
[1] Univ Cambridge, Dept Pathol, Cambridge CB2 1QP, England
来源：
INFECTIOUS DISEASES AND NANOMEDICINE II | 2014年 / 808卷
基金：
英国惠康基金; 英国医学研究理事会;
关键词：
Vaccinia virus; Smallpox vaccine; Immune evasion; Virus spreading mechanism; EXTRACELLULAR ENVELOPED VIRUS; ACTIN-BASED MOTILITY; TO-CELL SPREAD; HEMAGGLUTININ GENE; A33R PROTEIN; RECOGNITION; DNA; CONSTRUCTION; MICROTUBULES; EXPRESSION;
D O I：
10.1007/978-81-322-1774-9_6
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Vaccinia virus (VACV) is the live vaccine that was used to eradicate smallpox, a feat achieved in 1977 and certified by the World Health Organization in 1980. Since 1980, research with VACV has continued in part because of the development of techniques to genetically manipulate VACV and create live VACV strains expressing foreign genes. These recombinant VACVs can be used as live vaccines against other infectious diseases and cancers, and as a powerful tool to study virus pathogenesis, immunology, cell biology, and virus-host interactions. This short article describes two examples of how enduring interest in VACV has revealed new features of VACV biology and the immune system.
引用
收藏
页码：65 / 76
页数：12
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