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Treatment Adherence to Different Etanercept Regimens, Continuous vs. Intermittent, in Patients Affected by Plaque-Type Psoriasis
被引:11
|作者:
Esposito, Maria
[1
]
Gisondi, Paolo
[2
]
Cassano, Nicoletta
[3
]
Babino, Graziella
[1
]
Cannizzaro, Maria Vittoria
[1
]
Ferrucci, Giuliano
[4
]
Chimenti, Sergio
[1
]
Giunta, Alessandro
[1
]
机构:
[1] Univ Roma Tor Vergata, Dept Dermatol, I-00133 Rome, Italy
[2] Univ Verona, Sect Dermatol & Venereol, Dept Med, I-37100 Verona, Italy
[3] Univ Bari, Unit Dermatol & Venereol, Dept Biomed Sci & Human Oncol, Bari, Italy
[4] Informa Srl, Rome, Italy
关键词:
adherence;
anti-tumor necrosis factor alpha (anti-TNF-);
etanercept;
psoriasis;
DRUG SURVIVAL RATES;
VULGARIS;
D O I:
10.1002/ddr.21190
中图分类号:
R914 [药物化学];
学科分类号:
100701 ;
摘要:
Treatment adherence to anti-tumor necrosis factor alpha (anti-TNF-) agents is marker of treatment success, but overall efficacy of anti-TNF- therapy decreases over time leading to a progressive loss of adherence. The present observational study was conducted in order to estimate the long-term adherence to etanercept in patients affected by plaque-type psoriasis, evaluating differences among intermittent and continuous treatment regimen. Our findings reflect routine clinical practice in three academic referral centers and show high treatment adherence with etanercept in psoriatic patients. Treatment survival was consistently high in the short/medium term. The univariate analysis showed longer treatment duration in patients undergoing intermittent treatment regimen (mean 1,706days) compared with continuous regimen (mean 1,249days). Results showed that a flexible pulsed treatment with etanercept can be optimal in terms of clinical success and adherence.
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页码:S31 / S34
页数:4
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