Cobalt-catalyzed nucleophilic addition of the allylic C(sp3)-H bond of simple alkenes to ketones

被引：12
|
作者：
Mita, Tsuyoshi [1 ]
Uchiyama, Masashi [1 ]
Michigami, Kenichi [1 ]
Sato, Yoshihiro [1 ]
机构：
[1] Hokkaido Univ, Fac Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan
来源：
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 14卷
关键词：
alkenes; C-H activation; C(sp(3))-H bonds; cobalt; ketones; CARBOXYLATION; FUNCTIONALIZATION; OLEFINS; ACTIVATION; ALLYLATION; COMPLEXES; OXIDATION; UMPOLUNG;
D O I：
10.3762/bjoc.14.176
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We herein describe a cobalt/Xantphos-catalyzed regioselective addition of simple alkenes to acetophenone derivatives, affording branched homoallylic alcohols in high yields with perfect branch selectivities. The intermediate of the reaction would be a nucleophilic allylcobalt(I) species generated via cleavage of the low reactive allylic C(sp(3))-H bond of simple terminal alkenes.
引用
收藏
页码：2012 / 2017
页数：6
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