In this work we analyze how the encounters and interactions between the cross, the subjects and the sites within the framework of the Jesuit missions carried out during the 17th century are embodied in the landscape of the Quebrada de Humahuaca. From the perspective of the "inhabit" of Ingold (2000), from which the landscape is conceived as a work in permanent construction structured in the assembly of different "taskscape", we delimit and explore three activities whose center was the cross: "evangelize with the cross", "celebrate the cross" and "place the cross". For this, we review a corpus of ecclesiastical written discourses (Letters Anuas, 1672-1675; del Techo, 1897 [1673]; Lozano, 1941 [1733]; Vergara, 1932, 1965) and visuals (paintings, cartography and rock art).