Direct asymmetric aldol reaction catalyzed by simple prolinamide phenols

被引：94
|
作者：
Fu, Yu-Qin [1 ]
Li, Zai-Chun [1 ]
Ding, Ll-Na [1 ]
Tao, Jing-Chao [1 ]
Zhang, Sheng-Hong [1 ]
Tang, Ming-Sheng [1 ]
机构：
[1] Zhengzhou Univ, Dept Chem, New Drug Res & Dev Ctr, Zhengzhou 450052, Peoples R China
来源：
TETRAHEDRON-ASYMMETRY | 2006年 / 17卷 / 24期
基金：
中国国家自然科学基金;
关键词：
D O I：
10.1016/j.tetasy.2006.12.008
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Simple prolinamides 1a-f were synthesized, and their catalytic effects on the direct asymmetric aldol reactions in organic solvents and in water were evaluated. Prolinamide phenols 1a-d were found to be effective catalysts for the reaction of aromatic aldehydes with cyclohexanone in neat ketone and in water. The anti-aldol products were obtained with up to 98/2 anti/syn ratio and 96% ee in neat ketone, 98/2 anti/syn ratio and 99% ee in water, respectively. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3351 / 3357
页数：7
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