New naphthylcombretastatins.: Modifications on the ethylene bridge

被引：29
|
作者：
Maya, ABS
Pérez-Melero, C
Salvador, N
Peláez, R
Caballero, E
Medarde, M
机构：
[1] Univ Salamanca, Fac Farm, Lab Quim Organ & Farmaceut, E-37007 Salamanca, Spain
[2] Inst Biomar SA, Leon 24231, Spain
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2005年 / 13卷 / 06期
关键词：
combretastatin analogues; naphthalene; heterocycle bridged; cytotoxicity; tubulin polymerization inhibition;
D O I：
10.1016/j.bmc.2005.01.012
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Compounds with three aromatic systems, carrying a 2-naphthalene and a 3,4,5-trimethoxyphenyl moieties bonded to five-membered, six-membered or fused heterocycles display potent cytotoxic effect and inhibition of tubulin polymerization, in agreement with their structural similarity to combretastatins and their heterocyclic analogues. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2097 / 2107
页数：11
相关论文
共 50 条
  • [1] Further naphthylcombretastatins.: An investigation on the role of the naphthalene moiety
    Maya, ABS
    Pérez-Melero, C
    Mateo, C
    Alonso, D
    Fernández, JL
    Gajate, C
    Mollinedo, F
    Peláez, R
    Caballero, E
    Medarde, M
    JOURNAL OF MEDICINAL CHEMISTRY, 2005, 48 (02) : 556 - 568
  • [2] MODIFICATIONS OF VIENNA BRIDGE OSCILLATORS
    STORJOHANN, J
    INTERNATIONALE ELEKTRONISCHE RUNDSCHAU, 1975, 29 (06): : 121 - 124
  • [3] TOWER MODIFICATIONS TO BRITANNIA-BRIDGE
    BAVISTER, RB
    CONCRETE, 1974, 8 (04): : 58 - 58
  • [4] MODIFICATIONS OF WIEN-BRIDGE-OSCILLATOR
    STORJOHANN, J
    INTERNATIONALE ELEKTRONISCHE RUNDSCHAU, 1975, 29 (09): : 207 - 209
  • [5] NICKEL ELECTROCRYSTALLIZATION MODIFICATIONS BY ETHYLENE COMPOUNDS
    FROMENT, M
    GEORGOUL.C
    GOFF, AHL
    COMPTES RENDUS HEBDOMADAIRES DES SEANCES DE L ACADEMIE DES SCIENCES SERIE C, 1968, 267 (18): : 1099 - &
  • [6] Novel modifications of poly(ethylene imine)
    Schubert, Ulrich
    Englert, Christoph
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 252
  • [7] New Bis-o-Benzoquinoid Ligands with Ethylene Bridge and Their Metal Complexes
    Poddel'sky, Andrey I.
    Piskunov, Alexander V.
    Druzhkov, Nikolay O.
    Fukin, Georgii K.
    Cherkasov, Vladimir K.
    Abakumov, Gleb A.
    ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE, 2009, 635 (15): : 2563 - 2571
  • [8] Modifications of the resistance thermometer bridge (Mueller bridge) and of the commutator selector for use with it
    Eppley, M
    REVIEW OF SCIENTIFIC INSTRUMENTS, 1932, 3 (11): : 687 - 706
  • [9] DURHAMS NEW BRIDGE - NEW ELVET BRIDGE
    不详
    CONCRETE QUARTERLY, 1975, (105): : 16 - 17
  • [10] Study of the Composition and Morphology of New Modifications of Titanium-Magnesium Catalysts with Improved Properties in Ethylene Polymerization
    Mikenas, Tatiana B.
    Koshevoy, Evgeny I.
    Cherepanova, Svetlana V.
    Zakharov, Vladimir A.
    JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 2016, 54 (16) : 2545 - 2558
12345