pH and Redox Dual-Response Disulfide Bond-Functionalized Red-Emitting Gold Nanoclusters for Monitoring the Contamination of Organophosphorus Pesticides in Foods

被引：85

作者：

Li, Qian ^{[1
]}

Wu, Jiahui ^{[1
]}

Yang, Qiaoting ^{[1
]}

Li, Haiyin ^{[1
]}

Li, Feng ^{[1
]}

机构：

[1] Qingdao Agr Univ, Coll Chem & Pharmaceut Sci, Qingdao 266109, Peoples R China

来源：

ANALYTICAL CHEMISTRY | 2021年 / 93卷 / 19期

基金：

中国国家自然科学基金;

关键词：

SENSITIVE DETECTION; ACETYLCHOLINESTERASE; EMISSION; NANOMATERIALS; ENHANCEMENT; DOTS;

D O I：

10.1021/acs.analchem.1c01414

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Most of the fluorescence sensors require choline oxidase or quenchers to detect organophosphorus pesticides (OPs) based on a single hydrolysate and suffer from high cost, complex procedures, weak stability, and low sensitivity. Here, we proposed a brand-new fluorescence strategy for highly sensitive detection of OPs based on both hydrolysate-response disulfide bond-functionalized gold nanoclusters (S-S-AuNCs) without additional substances. S-S-AuNCs were synthesized via a facile one-step redox reaction and emitted bright red light with ultrasmall size and high water dispersion. Interestingly, S-S-AuNCs displayed a unique response to thiol compounds and low pH values and were thus pioneered as a high-efficiency sensor for OPs based on acetylcholinesterase (AChE)-catalyzed hydrolysis of acetylthiocho-line into thiocholine and CH3COOH and OP inhibition of AChE activity. Further, S-S-AuNCs were employed to monitor the residue, distribution, and metabolization of methidathion in pakchoi with acceptable results. We believe that this work supplies a simpler and more highly sensitive approach for OP assay than the known ones and opens a new avenue to development of multistimulus-responsive and high-performance fluorescence substances.

引用

页码：7362 / 7368

页数：7