Effect of Season of Birth on Hippocampus Volume in a Transdiagnostic Sample of Patients With Depression and Schizophrenia

被引：2

作者：

Schaub, Nora ^{[1
]}

Ammann, Nina ^{[1
]}

Conring, Frauke ^{[1
]}

Mueller, Thomas ^{[1
]}

Federspiel, Andrea ^{[1
]}

Wiest, Roland ^{[2
]}

Hoepner, Robert ^{[3
,4
]}

Stegmayer, Katharina ^{[1
]}

Walther, Sebastian ^{[1
]}

机构：

[1] Univ Hosp Psychiat & Psychotherapy, Translat Res Ctr, Bern, Switzerland

[2] Inselspital Bern, Univ Inst Diagnost & Intervent Neuroradiol, Support Ctr Adv Neuroimaging SCAN, Bern, Switzerland

[3] Inselspital Bern, Univ Hosp, Dept Neurol, Bern, Switzerland

[4] Univ Bern, Bern, Switzerland

来源：

FRONTIERS IN HUMAN NEUROSCIENCE | 2022年 / 16卷

基金：

瑞士国家科学基金会;

关键词：

depression; schizophrenia; season of birth; structural neuroimaging; hippocampus; gray matter; PRENATAL IMMUNE CHALLENGE; GRAY-MATTER ABNORMALITIES; VOXEL-BASED MORPHOMETRY; 1ST-EPISODE SCHIZOPHRENIA; BRAIN VOLUME; GREY-MATTER; PSYCHOMOTOR RETARDATION; VENTRICULAR ENLARGEMENT; BIPOLAR DISORDER; INFECTION LEADS;

D O I：

10.3389/fnhum.2022.877461

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Psychiatric disorders share an excess of seasonal birth in winter and spring, suggesting an increase of neurodevelopmental risks. Evidence suggests season of birth can serve as a proxy of harmful environmental factors. Given that prenatal exposure of these factors may trigger pathologic processes in the neurodevelopment, they may consequently lead to brain volume alterations. Here we tested the effects of season of birth on gray matter volume in a transdiagnostic sample of patients with schizophrenia and depression compared to healthy controls (n = 192). We found a significant effect of season of birth on gray matter volume with reduced right hippocampal volume in summer-born compared to winter-born patients with depression. In addition, the volume of the right hippocampus was reduced independent from season of birth in schizophrenia. Our results support the potential impact of season of birth on hippocampal volume in depression.

引用

页数：10

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