Present status of quinoxaline motifs: Excellent pathfinders in therapeutic medicine

被引：105
|
作者：
Ajani, Olayinka Oyewale [1 ]
机构：
[1] Covenant Univ, Coll Sci & Technol, Sch Nat & Appl Sci, Dept Chem, Ota, Ogun State, Nigeria
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2014年 / 85卷
关键词：
Nitrogen heterocycles; In vitro; Therapeutics; Mycobacterium tuberculosis; Echinomycin; SOLID-PHASE SYNTHESIS; MICROWAVE-ASSISTED SYNTHESIS; VITRO ANTIBACTERIAL ACTIVITY; IN-VITRO; BIOLOGICAL EVALUATION; ANTIMICROBIAL ACTIVITY; RECEPTOR ANTAGONISTS; EFFICIENT SYNTHESIS; N-1; N-4-DIOXIDE DERIVATIVES; 1,4-DI-N-OXIDE DERIVATIVES;
D O I：
10.1016/j.ejmech.2014.08.034
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Quinoxalines belong to a class of excellent heterocyclic scaffolds owing to their wide biological properties and diverse therapeutic applications in medicinal research. They are complementary in shapes and charges to numerous biomolecules they interact with, thereby resulting in increased binding affinity. The pharmacokinetic properties of drugs bearing quinoxaline cores have shown them to be relatively easy to administer either as intramuscular solutions, oral capsules or rectal suppositories. This work deals with recent advances in the synthesis and pharmacological diversities of quinoxaline motifs which might pave ways for novel drugs development. (C) 2014 Elsevier Masson SAS. All rights reserved.
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页码：688 / 715
页数：28
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