Screening for Antibacterial Activity of French Mushrooms against Pathogenic and Multidrug Resistant Bacteria

被引:9
|
作者
Huguet, Clement [1 ]
Bourjot, Melanie [1 ]
Bellanger, Jean-Michel [2 ]
Prevost, Gilles [3 ]
Urbain, Aurelie [1 ]
机构
[1] Univ Strasbourg, Inst Pluridisciplinaire Hubert Curien, Fac Pharm, CAMBAP,CNRS,UMR 7178, F-67081 Strasbourg, France
[2] Univ Montpellier, CNRS, INSERM, CEFE,EPHE,IRD, F-34090 Montpellier, France
[3] Univ Strasbourg, Inst Bacteriol, UR 7290, F-67081 Strasbourg, France
来源
APPLIED SCIENCES-BASEL | 2022年 / 12卷 / 10期
关键词
antibiotic resistance; mushrooms; antibacterial; screening; direct bioautography; thin-layer chromatography; FREE FATTY-ACIDS;
D O I
10.3390/app12105229
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
In the alarming context of antibiotic resistance, we explored the antibacterial potential of French mushrooms against wild-type and multidrug-resistant (MDR) bacteria. In order to accelerate the discovery of promising compounds, screenings were carried out by TLC-direct bioautography. A total of 70 extracts from 31 mushroom species were evaluated against five wild-type bacteria: Staphylococcus epidermidis, Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, and Pseudomonas aeruginosa. This first screening revealed that 95% of the extracts contained antibacterial compounds. Generally, it was observed that EtOAc extracts exhibited more active compounds than methanolic extracts. In addition, all extracts were overall more active against Gram-positive bacteria than against Gram-negative strains. The most promising mushroom extracts were then screened against various multidrug-resistant strains of S. aureus and E. coli. Activity was globally less on MDR strains; however, two mushroom species, Fomitopsis pinicola and Scleroderma citrinum, still contained several compounds inhibiting the growth of these MDR pathogenic bacteria. Stearic acid was identified as a ubiquitous compound contributing to the antibacterial defence of mushrooms. This screening revealed the potential of macromycetes as a source of antibacterial compounds; further assays are necessary to consider fungal compounds as promising drugs to counter antibiotic resistance.
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页数:18
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